Frontiers in Pharmacology, 2022 Ayurvedic medicines Withania somnifera Dunal (ashwagandha) and AYUSH-64 have been used for the prevention and management of COVID-19 in India. The present study explores the effect of Ashwagandha and AYUSH-64 on important human CYP enzymes (CYP3A4 ...
Siva Swapna Kasarla +7 more
doaj +1 more source
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]
, 2019 Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska +9 more
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Effect of CYP2C8 genotype on rosiglitazone pharmacokinetics [PDF]
Clinical Pharmacology & Therapeutics, 2005 Background/Aims The purpose of this study was to investigate the effect of the CYP2C8 genetic polymorphisms CYP2C8*2, CYP2C8*3, and CYP2C8*4 on the pharmacokinetics of rosiglitazone, a PPARγ agonist and CYP2C8 substrate. Methods This single dose pharmacokinetics study involved thirty-eight healthy subjects with the following CYP2C8 ...
M HRUSKA +4 more
openaire +3 more sources
Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]
, 2012 The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco +18 more
core +4 more sources
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]
, 2016 Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB +14 more
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In vitro inhibitory effect of lysionotin on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2020 Context Lysionotin, a major extraction of Lysionotus pauciflorus Maxim (Gesneriaceae), has a variety of pharmacological properties commonly used in the treatment of lung disease.
Yang Li +7 more
doaj +1 more source
Association of warfarin dose with genes involved in its action and metabolism [PDF]
, 2007 We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin.
Mia Wadelius +73 more
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Effect of pterostilbene on in vitro drug metabolizing enzyme activity
Saudi Pharmaceutical Journal, 2019 Pterostilbene is a natural polyphenol compound found in small berries that is related to resveratrol, but has better bioavailability and a longer half-life.
Ahmed A. Albassam, Reginald F. Frye
doaj +1 more source
G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model [PDF]
, 2013 Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways.
Alonso, Silvia del Valle +6 more
core +2 more sources
The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients
Balkan Journal of Medical Genetics, 2016 The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD +7 more
doaj +1 more source