Results 51 to 60 of about 14,735 (228)
CYP2C8 and CYP2C9 mRNA expression profile in the human fetus
Frontiers in Genetics, 2014 CYP2C8 and CYP2C9 are involved in the inactivation of several NSAIDs, including ibuprofen. CYP2C9 is the major form in human liver whereas CYP2C8 has been proposed to be the main CYP2C enzyme in fetal liver.
Maria eJohansson +3 more
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Biomedical Papers, 2022 Aims. Hofbauer cells (HBCs) are placental macrophages playing various roles during normal and complicated pregnancies, and of the latter, chorioamnionitis is the most frequent. Methods.
Zdenek Tauber, Katerina Cizkova
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Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]
, 2019 Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
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Pharmaceutical Biology, 2022 Context Ginkgo leaf tablet (GLT), a traditional Chinese herbal formula, is often combined with rosiglitazone (ROS) for type 2 diabetes mellitus treatment. However, the drug-drug interaction between GLT and ROS remains unknown.Objective To investigate the
Xueting Xing +7 more
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Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma [PDF]
, 2005 Background Cytochrome P450 (CYP) enzymes in epithelial cells lining the alimentary tract play an important role in both the elimination and activation of (pro-)carcinogens.
Ina Bergheim +29 more
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Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population [PDF]
, 2017 Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding
Bykanova, M. +4 more
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CYP2C8 Exists as a Dimer in Natural Membranes [PDF]
Drug Metabolism and Disposition, 2010 CYP2C8 with a modified N-terminal sequence (2C8H) crystallizes as a dimer, but it is not known whether native CYP2C8 exists as a dimer in natural membranes. We have examined the organization of 2C8H and CYP2C8 expressed in bacterial membranes and mammalian endoplasmic reticulum membranes, respectively, by cysteine scanning and cross-linking or ...
Gang, Hu, Eric F, Johnson, Byron, Kemper
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Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]
, 2016 Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R. +7 more
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Journal of Hepatocellular Carcinoma, 2021 Xin Zhou,1,2,* Tian-Man Li,1– 3,* Jian-Zhu Luo,1,2,* Chen-Lu Lan,1,2 Zhong-Liu Wei,1,2 Tian-Hao Fu,1,2 Xi-Wen Liao,1,2 Guang-Zhi Zhu,1,2 Xin-Ping Ye,1,2 Tao Peng1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhou X +9 more
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Journal of Pharmacological Sciences, 2005 Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified.
Ryoko Taniguchi +6 more
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