Results 31 to 40 of about 14,735 (228)

Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning [PDF]

Frontiers in Genetics
ObjectiveAs a leading cause of cancer-related mortality, liver cancer was associated with metabolic dysregulation. We aimed to identify metabolism-related prognostic biomarkers and therapeutic targets.MethodsTranscriptomic data from TCGA were analyzed ...
Taorui Wang, Zijun Lai, Shengjun Tang, Lehang Lin, Mingjiao Zhang   +4 more
doaj   +2 more sources

CYP2C8 wt Allele [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

CYP2C8*3 Allele [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Improving the accuracy of prediction models for small datasets of Cytochrome P450 inhibition with deep learning [PDF]

Journal of Cheminformatics
The cytochrome P450 (CYP) superfamily metabolises a wide range of compounds; however, drug-induced CYP inhibition can lead to adverse interactions. Identifying potential CYP inhibitors is crucial for safe drug administration.
Elpri Eka Permadi, Reiko Watanabe, Kenji Mizuguchi   +2 more
doaj   +2 more sources

CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups

Терапевтический архив, 2021
Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks. Materials and methods.
Sherzod P. Abdullaev, Natalia P. Denisenko, Karin B. Mirzaev, Gregorii N. Shuev, Zhannet A. Sozaeva, Anastasia A. Kachanova, Suleiman N. Mammaev, Elvira A. Kasaeva, Danial M. Gafurov, Elena A. Grishina, Dmitry A. Sychev   +10 more
doaj   +1 more source

Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

Malaria Journal, 2021
Background The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8).
Leyre Pernaute-Lau, Ulrika Morris, Mwinyi Msellem, Andreas Mårtensson, Anders Björkman, Jose Pedro Gil   +5 more
doaj   +1 more source

Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome

Терапевтический архив, 2022
Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain. Materials and methods.
Andranik A. Muradian, Dmitry A. Sychev, Dmitry A. Blagovestnov, Demyan I. Petrov, Dmitry S. Skukin, Irina P. Epifanova, Zhannet A. Sozaeva, Anastasia A. Kachanova, Natalia P. Denisenko, Sherzod P. Abdullaev, Elena A. Grishina   +10 more
doaj   +1 more source

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +8 more sources

Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles

Pharmaceutical Biology, 2022
Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food.
Shun-bin Luo, Er-min Gu, Yu-ao Chen, Shi-chen Zhou, Chen Fan, Ren-ai Xu   +5 more
doaj   +1 more source

Structure of the distribution of genetic determinants of the efficacy and safety of non-steroidal anti-inflammatory drugs in the Russian population: focus on CYP2C8, PTGS1 and PTGS2

Современная ревматология, 2022
The efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) may be determined by the polymorphic nature of the CYP2C8, PTGS1 and PTGS2 genes.Objective: to analyze the nature of the distribution of CYP2C8*3 (rs10509681), CYP2C8*3 (rs11572080)
N. P. Denisenko, Sh. P. Abdullaev, K. A. Akmalova, Zh. A. Sozaeva, A. A. Kachanova, M. S-Kh. Sozaeva, L. Z. Bolieva, E. A. Grishina, D. A. Sychev   +8 more
doaj   +1 more source