Results 31 to 40 of about 10,726 (197)
The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility
Frontiers in Endocrinology, 2022 BackgroundBladder cancer is the most common leading cause of mortality around the world. Previous studies have indicated that genetic factors are significantly associated with bladder cancer progression—for instance, the CYP2C8 gene is involved in ...
Weixing Qu +4 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2016 PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity
Toshiro Niwa, Yurie Imagawa
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CYP2C8 Exists as a Dimer in Natural Membranes [PDF]
Drug Metabolism and Disposition, 2010 CYP2C8 with a modified N-terminal sequence (2C8H) crystallizes as a dimer, but it is not known whether native CYP2C8 exists as a dimer in natural membranes. We have examined the organization of 2C8H and CYP2C8 expressed in bacterial membranes and mammalian endoplasmic reticulum membranes, respectively, by cysteine scanning and cross-linking or ...
Gang, Hu, Eric F, Johnson, Byron, Kemper
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Frontiers in Pharmacology, 2015 The cytochrome P450, CYP2C8, metabolises more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid.
Maria eThomas +7 more
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Biomedical Papers, 2022 Aims. Hofbauer cells (HBCs) are placental macrophages playing various roles during normal and complicated pregnancies, and of the latter, chorioamnionitis is the most frequent. Methods.
Zdenek Tauber, Katerina Cizkova
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Impact of CYP2C8 single nucleotide polymorphisms on in-vitro metabolism of imatinib to N-desmethyl imatinib [PDF]
, 2015 Imatinib is a first line therapy for the treatment of chronic myeloid leukaemia (CML). Treatment with imatinib must be continuous and indefinite for most patients to maintain disease control.
Khan, Muhammad Suleman
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Pharmaceutical Biology, 2022 Context Ginkgo leaf tablet (GLT), a traditional Chinese herbal formula, is often combined with rosiglitazone (ROS) for type 2 diabetes mellitus treatment. However, the drug-drug interaction between GLT and ROS remains unknown.Objective To investigate the
Xueting Xing +7 more
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Journal of Hepatocellular Carcinoma, 2021 Xin Zhou,1,2,* Tian-Man Li,1– 3,* Jian-Zhu Luo,1,2,* Chen-Lu Lan,1,2 Zhong-Liu Wei,1,2 Tian-Hao Fu,1,2 Xi-Wen Liao,1,2 Guang-Zhi Zhu,1,2 Xin-Ping Ye,1,2 Tao Peng1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhou X +9 more
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Journal of Pharmacological Sciences, 2005 Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified.
Ryoko Taniguchi +6 more
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CYP3A4*20, CYP3A4*22, CYP2C8*3 and SLCO1B1 as genetic biomarkers to predict peripheral neuropathy induced by paclitaxel and docetaxel: A systematic review [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cancer is a global health problem with a growing incidence year after year, and it is projected that by 2040, there will be more than 2.4 million cases in Latin America and the Caribbean, being the second cause of death in these countries.
Angel T. Alvarado +16 more
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