CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride
Clinical and Translational Science, 2022 Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease.
Diana María Campodónico +12 more
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Genetic polymorphism of CYP2C8*4 in a healthy Turkish population [PDF]
Medicine Science, 2020 Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds.
Zuhal Uckun Sahinogullari
doaj +8 more sources
CYP2C8 and CYP2C9 mRNA expression profile in the human fetus [PDF]
Frontiers in Genetics, 2014 CYP2C8 and CYP2C9 are involved in the inactivation of several NSAIDs, including ibuprofen. CYP2C9 is the major form in human liver whereas CYP2C8 has been proposed to be the main CYP2C enzyme in fetal liver.
Maria eJohansson +3 more
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Acta Medica Lituanica, 2017 Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium.
Rasa Liutkevičienė +6 more
doaj +2 more sources
Pharmacokinetics and pharmacodynamics of rosiglitazone in elation to CYP2C8 genotype
Clinical Pharmacology & Therapeutics, 2006 Objectives: Rosiglitazone is metabolically inactivated predominantly via the cytochrome P450 (CYP) enzyme CYP2C8. The functional impact of the CYP2C8 3 allele coding for the Arg139Lys and Lys399Arg amino acid substitutions is controversial.
Tomalik-Scharte, Dorota +11 more
core +4 more sources
Effect of the CYP2C8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide
Drug Metabolism and Disposition, 2011 The pharmacokinetics of repaglinide shows pronounced interindividual variability, for which several reasons have been considered, including interactions with drugs inhibiting CYP2C8 and CYP2C8 genetic polymorphism.
Frank, D +13 more
core +3 more sources
The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients
Balkan Journal of Medical Genetics, 2016 The aim of the present study was to investigate the distribution of CYP2C8 variants *3 and *5, as well as their effect on carbamazepine pharmacokinetic properties, in 40 epileptic pediatric patients on carbamazepine treatment.
Milovanovic DD +7 more
doaj +3 more sources
Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences [PDF]
Human GenomicsBackground CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory drugs.
Mahamadou D. Camara +5 more
doaj +2 more sources
Characterisation of
BMC Medical Genetics, 2009 Background Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity.
Dodoo Alexander NO +2 more
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Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis. [PDF]
ChembiochemCytochrome P450 2C8 (CYP2C8) is known to cause drug interactions via pharmacokinetic alterations of drugs, but it’s also explicitly crucial for endogenous metabolism, like the generation of epoxyeicosatrienoic acids (EETs) from arachidonic acid.
Dhiman S +9 more
europepmc +2 more sources