CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride
Clinical and Translational Science, 2022 Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease.
Diana María Campodónico +12 more
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Evaluation of CYP2C8 and CYP2C9 Polymorphisms in Neonates with Patent Ductus Arteriosus Treated with Ibuprofen or Indomethacin: A Retrospective Cohort Study [PDF]
Journal of Cardiovascular Development and DiseaseThe pharmacologic management of patent ductus arteriosus (PDA) presents a challenge to clinicians due to the interindividual variability in drug response to available medications.
Shaikha Jabor Alnaimi +10 more
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Genetic polymorphism of CYP2C8*4 in a healthy Turkish population [PDF]
Medicine Science, 2020 Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds.
Zuhal Uckun Sahinogullari
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CYP2C8 and Antimalaria Drug Efficacy [PDF]
Pharmacogenomics, 2007 Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million people, mainly small children in Africa. The highly efficacious artemisinine combination therapy is being launched globally, constituting the main hope for fighting the disease. Amodiaquine is a main partner in these combinations.
José Pedro Gil, Eva Gil Berglund
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Analysis of the functional polymorphism in the cytochrome P450 CYP2C8 gene rs11572080 with regard to colorectal cancer risk [PDF]
Frontiers in Genetics, 2012 In addition to the known effects on drug metabolism and response, functional polymorphisms of genes coding for xenobiotic-metabolizing enzymes (XME) play a role in cancer.
José M Ladero +5 more
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Association of CYP2C9∗3 and CYP2C8∗3 Non-Functional Alleles with Ibuprofen-Induced Upper Gastrointestinal Toxicity in a Saudi Patient [PDF]
Case Reports in Medicine, 2023 Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used to alleviate pain and inflammation. Although it is generally considered safe, common adverse drug reactions of ibuprofen include stomach pain, nausea, and heartburn.
Amina M. Bagher
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Comparative analysis of CYP2C8-medidated drug-drug interactions produced by CYP2C8 inhibitors, gemfibrozil versus clopidogrel, focusing on the inhibition of drug distribution in UDP-glucuronosyltransferase prior to oxidation [PDF]
Drug Metabolism and Disposition, 2023 The glucose-lowering drug pioglitazone undergoes hepatic CYP2C8-mediated biotransformation to its main metabolites. The antiplatelet drug clopidogrel is metabolized to clopidogrel acyl-β-d-glucuronide, which was recently found to be a strong time-dependent inhibitor of CYP2C8 in humans.
Katsumi Iga, Akiko Kiriyama
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Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8 [PDF]
Frontiers in Pharmacology, 2015 The cytochrome P450, CYP2C8, metabolises more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid.
Maria eThomas +7 more
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The contribution of CYP2C gene subfamily involved in epoxygenase pathway of arachidonic acids metabolism to hypertension susceptibility in Russian population [PDF]
Clinical and Experimental Hypertension, 2017 Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway of arachidonic acids metabolism for the pathogenesis of essential hypertension (EH).
Alexey Polonikov +11 more
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Amiodarone N‐Deethylation by CYP2C8 and its Variants, CYP2C8*3 and CYP2C8 P404A [PDF]
Pharmacology & Toxicology, 2002 Abstract: Amiodarone is a potent Class III antiarrhythmic drug. The N‐deethylation of amiodarone to desethylamiodarone is known to be catalyzed by cytochrome P450 (CYP) 2C8. In the present study, amiodarone N‐deethylation by the CYP2C8s, CYP2C8*1 (wild‐type), CYP2C8*3, and CYP2C8 P404A (Pro404Ala substitution in exon 8), was investigated by their ...
Akiko Soyama +6 more
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