Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges [PDF]
Biomolecules, 2022 The lipid-regulating drug gemfibrozil is a useful medication for reducing high cholesterol and triglycerides in the blood. In addition to oxidation, it undergoes extensive glucuronidation to produce gemfibrozil acyl glucuronide, which is a known ...
Manish B. Shah
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CYP2C8 Status of Patients With Malaria Influences Selection of Plasmodium falciparum pfmdr1 Alleles After Amodiaquine-Artesunate Treatment [PDF]
, 2012 info:eu-repo/semantics ...
Isa Cavaco +5 more
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Characterisation of
BMC Medical Genetics, 2009 Background Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity.
Dodoo Alexander NO +2 more
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Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences [PDF]
Human GenomicsBackground CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory drugs.
Mahamadou D. Camara +5 more
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Global variation in CYP2C8–CYP2C9 functional haplotypes [PDF]
Pharmacogenomics Journal, 2009 We have studied the global frequency distributions of 10 single nucleotide polymorphisms (SNPs) across 132 kb of CYP2C8 and CYP2C9 in approximately 2500 individuals representing 45 populations. Five of the SNPs were in noncoding sequences; the other five involved the more common missense variants (four in CYP2C8, one in CYP2C9) that change amino acids ...
Kenneth K Kidd
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Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35 [PDF]
Pharmaceutics, 2021 Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction ...
Chengming Wen +5 more
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In Silico Dock of TKIs with CYP3A4 and CYP2C8 and Pharmacophore Generation [PDF]
BIO Web of ConferencesTyrosine kinase inhibitors (TKIs) serve as targeted anticancer drugs that inhibit the abnormal activity of tyrosine kinase (TK) in cancer treatment. However, when used with other medications, they often result in side effects, such as renal impairment ...
Ma Zhenya
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PLoS ONE, 2010 BackgroundPatent ductus arteriosus (PDA) in extremely preterm infants remains a challenging condition with conflicting treatment strategies. Ibuprofen is currently used to treat PDA with ductal closure failure rate up to 40%.
Xavier Durrmeyer +9 more
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The Effect of Flavonoid Aglycones on the CYP1A2, CYP2A6, CYP2C8 and CYP2D6 Enzymes Activity
Molecules, 2019 Cytochromes P450 are major metabolic enzymes involved in the biotransformation of xenobiotics. The majority of xenobiotics are metabolized in the liver, in which the highest levels of cytochromes P450 are expressed.
Mirza Bojić +2 more
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