Results 1 to 10 of about 14,735 (228)

Pharmacogenetic Aspects of Postoperative Anesthesia with Ketoprofen in Cardiac Surgery Patients

Рациональная фармакотерапия в кардиологии, 2021
Aim. Evaluation of the effect of polymorphisms of the CYP2D6, CYP2C8 genes on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery.Material and methods.
T. E. Morozova, D. A. Shatsky, N. V. Shikh, E. V. Shikh, T. B. Andrushchyshina, M. V. Lukina, A. A. Kachanova, Z. A. Sozaeva, G. N. Shuev, N. P. Denisenko, E. А. Grishina, D. A. Sychev   +11 more
doaj   +1 more source

Pharmacokinetic interactions of pioglitazone [PDF]

, 2007
Pioglitazone is a thiazolidinedione compound used in the treatment of type 2 diabetes. It has been reported to be metabolised by multiple cytochrome P450 (CYP) enzymes, including CYP2C8, CYP2C9 and CYP3A4 in vitro.
Jaakkola, Tiina
core  

Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE

Lupus Science and Medicine, 2023
Objectives The study aims to investigate the impact of gene polymorphisms on blood hydroxychloroquine (HCQ) concentrations in patients with SLE and provide guidelines for individualised care.Methods 489 Chinese patients with SLE taking HCQ for more than ...
Lingyun Sun, Wei Shen, Ziyi Jin, Dandan Wang, Yizhun Zhu, Linyu Geng, Han Xie, Xin Wen, Yuchun Wang, Xuan Huang, Qing Shu, Weihong Ge   +11 more
doaj   +1 more source

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source

Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes

Pharmaceutics, 2021
Schisandra chinensis has been widely used as a traditional herbal medicine to treat chronic coughs, fatigue, night sweats, and insomnia. Numerous bioactive components including lignans have been identified in this plant.
Hyung-Ju Seo, Seung-Bae Ji, Sin-Eun Kim, Gyung-Min Lee, So-Young Park, Zhexue Wu, Dae Sik Jang, Kwang-Hyeon Liu   +7 more
doaj   +1 more source

Detection of Human CYP2C8, CYP2C9, and CYP2J2 in Cardiovascular Tissues [PDF]

Drug Metabolism and Disposition, 2007
The cytochrome P450 (P450) enzymes CYP2C8, CYP2C9, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids, which are known to be vital in regulation of vascular tone and cardiovascular homeostasis. Because there is limited information regarding the relative expression of these P450 enzymes in cardiovascular tissues, this study examined the
Tracy C, Delozier, Grace E, Kissling, Sherry J, Coulter, Diana, Dai, Julie F, Foley, J Alyce, Bradbury, Elizabeth, Murphy, Charles, Steenbergen, Darryl C, Zeldin, Joyce A, Goldstein   +9 more
openaire   +2 more sources

Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan [PDF]

, 2016
A list of SNPs that were not found in heterozygous or homozygous variants.
Aisha N. Iskakova, Akbota M. Aitkulova, Aliya A. Romanova, Elena V. Zholdybayeva, Erlan M. Ramanculov, Nurgul S. Sikhayeva   +5 more
core   +5 more sources

Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Human Genomics, 2008
Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans.
Aquilante Christina L, Bushman Lane R, Knutsen Shannon D, Burt Lauren E, Rome Lucille Capo, Kosmiski Lisa A   +5 more
doaj   +1 more source

Pharmacogenetics in type 2 diabetes:Influence on response to oral hypoglycemic agents [PDF]

, 2016
Adem Yesuf Dawed, Kaixin Zhou, Ewan Robert Pearson  Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Dundee, Scotland, UK Abstract: Type 2 diabetes is one of the leading causes of morbidity ...
Dawed, Adem Yesuf, Pearson, Ewan Robert, Zhou, Kaixin   +2 more
core   +4 more sources

Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria

Acta Medica, 2020
Background: A tremendous level of success has been achieved since the introduction of chloroquine and the combination of amodiaquine and artemisinin for the treatment of both complicated and uncomplicated malaria infections in sub-Saharan Africa. However,
Olalere Shittu, Olufunke Adenike Opeyemi, Olumuyiwa Babagbemi Omotesho, Oluwatosin Fakayode, Nnaemeka Asogwa, Opeyemi Margaret Adeniyi, Ifeoluwa Margaret Fatoba, Kayode Muritala Salawu, Olusola Ajibaye, Olarewaju Abdulkareem Babamale, Oluyinka Ajibola Iyiola, Olusola Isaac Aremu   +11 more
doaj   +1 more source