Results 1 to 10 of about 10,726 (197)

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure. [PDF]

Clin Pharmacol Ther
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Mykkänen AJH, Hirvensalo P, Klein K, Kaminska D, Grube M, Tapaninen T, Kiiski JI, Neuvonen M, Männistö VT, Pihlajamäki J, Tzvetkov M, Schwab M, Tornio A, Backman JT, Niemi M.   +14 more
europepmc   +2 more sources

Real-World Claims Data on Prescribed Drugs and the Associated Drug-Drug Interaction Risk in Sickle Cell Disease in the United States. [PDF]

Clin Transl Sci
Real‐world prescription data from 6230 adolescents and adults living with sickle cell disease (SCD) were combined with a drug–drug interaction (DDI) database to characterize the population‐level DDI risk. The findings support a DDI risk assessment for development of novel SCD therapies and during clinical management of SCD.ABSTRACTSickle cell disease ...
Nørgaard RA, Grenier L, Bruun-Rasmussen P, Osunkwo I, Säll C.   +4 more
europepmc   +2 more sources

Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim [PDF]

Antimicrobial Agents and Chemotherapy
Olorofim is a novel oral antifungal agent which selectively inhibits the fungal enzyme dihydroorotate dehydrogenase found in molds including Aspergillus, Scedosporium, Lomentospora, and Scopulariopsis and in dimorphic fungi such as Coccidioides. Based on
Karen Cornelissen, John H. Rex, Daniela Zinzi, Derek Law, Rachel Upcott Gill, Hannah M. Jones, Johan Maertens, Sharon C.-A. Chen, Roger Brüggemann   +8 more
doaj   +2 more sources

The DHCQ/HCQ metabolic ratio and CYP2C8 Genotype are associated with lipid profile improvement in systemic lupus erythematosus patients treated with hydroxychloroquine [PDF]

Arthritis Research & Therapy
Background Hydroxychloroquine (HCQ) improves the lipid profile in patients with systemic lupus erythematosus (SLE). Whether the lipid profile-improving efficacy of HCQ relates to its metabolism by cytochrome P450 (CYP450) enzymes remains unclear. Methods
Xue Zhao, Han Xie, Tengfei Shao, Weihong Ge, Yizhun Zhu, Ziyi Jin, Lingyun Sun   +6 more
doaj   +2 more sources

Evaluation of CYP2C8 and CYP2C9 Polymorphisms in Neonates with Patent Ductus Arteriosus Treated with Ibuprofen or Indomethacin: A Retrospective Cohort Study [PDF]

Journal of Cardiovascular Development and Disease
The pharmacologic management of patent ductus arteriosus (PDA) presents a challenge to clinicians due to the interindividual variability in drug response to available medications.
Shaikha Jabor Alnaimi, Shimaa Aboelbaha, Ibrahim Safra, Mai Abdulla Al Qubaisi, Fouad Abounahia, Ahmed Al Farsi, Liji Cherian, Lizy Philip, Moza Alhail, Gulab Sher, Nader Al-Dewik   +10 more
doaj   +2 more sources

Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning [PDF]

Frontiers in Genetics
ObjectiveAs a leading cause of cancer-related mortality, liver cancer was associated with metabolic dysregulation. We aimed to identify metabolism-related prognostic biomarkers and therapeutic targets.MethodsTranscriptomic data from TCGA were analyzed ...
Taorui Wang, Zijun Lai, Shengjun Tang, Lehang Lin, Mingjiao Zhang   +4 more
doaj   +2 more sources

CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups

Терапевтический архив, 2021
Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks. Materials and methods.
Sherzod P. Abdullaev, Natalia P. Denisenko, Karin B. Mirzaev, Gregorii N. Shuev, Zhannet A. Sozaeva, Anastasia A. Kachanova, Suleiman N. Mammaev, Elvira A. Kasaeva, Danial M. Gafurov, Elena A. Grishina, Dmitry A. Sychev   +10 more
doaj   +1 more source

Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

Malaria Journal, 2021
Background The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8).
Leyre Pernaute-Lau, Ulrika Morris, Mwinyi Msellem, Andreas Mårtensson, Anders Björkman, Jose Pedro Gil   +5 more
doaj   +1 more source

Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome

Терапевтический архив, 2022
Aim. To evaluate the possible association of CYP2C8 gene polymorphisms with the clinical efficacy and safety of ketorolac in relation to postoperative pain. Materials and methods.
Andranik A. Muradian, Dmitry A. Sychev, Dmitry A. Blagovestnov, Demyan I. Petrov, Dmitry S. Skukin, Irina P. Epifanova, Zhannet A. Sozaeva, Anastasia A. Kachanova, Natalia P. Denisenko, Sherzod P. Abdullaev, Elena A. Grishina   +10 more
doaj   +1 more source

Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges

Biomolecules, 2022
The lipid-regulating drug gemfibrozil is a useful medication for reducing high cholesterol and triglycerides in the blood. In addition to oxidation, it undergoes extensive glucuronidation to produce gemfibrozil acyl glucuronide, which is a known ...
Manish B. Shah
doaj   +1 more source