Results 131 to 140 of about 18,482 (146)
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Drug Metabolism and Disposition, 2002
CYP2C9 wild-type protein has been shown to exhibit atypical kinetic profiles of metabolism that may affect in vitro-in vivo predictions made during the drug development process. Previous work suggests a substrate-dependent effect of polymorphic variants of CYP2C9 on the rate of metabolism; however, it is hypothesized that these active site amino acid ...
Timothy S, Tracy +5 more
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CYP2C9 wild-type protein has been shown to exhibit atypical kinetic profiles of metabolism that may affect in vitro-in vivo predictions made during the drug development process. Previous work suggests a substrate-dependent effect of polymorphic variants of CYP2C9 on the rate of metabolism; however, it is hypothesized that these active site amino acid ...
Timothy S, Tracy +5 more
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Allele frequency distribution of CYP2C9*2 and CYP2C9*3 polymorphisms in six Mexican populations
Gene, 2013Allele frequency differences of functional CYP2C9 polymorphisms are responsible for some of the variation in drug response observed in human populations. The most relevant CYP2C9 functional variants are CYP2C9*2 (rs1799853) and CYP2C9 3 (rs1057910). These polymorphisms show variation in allele frequencies among different population groups.
Osvaldo D, Castelán-Martínez +9 more
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Molecular Pharmacology, 2001
CYP2C9 is a polymorphic gene for which there are four known allelic variants; CYP2C9*1, CYP2C9*2, CYP2C9*3, and CYP2C9*4. In the present study, DNA from 140 European Americans and 120 African Americans was examined by single-strand conformational polymorphism and restriction fragment length polymorphism analyses, resulting in the identification of a ...
L J, Dickmann +7 more
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CYP2C9 is a polymorphic gene for which there are four known allelic variants; CYP2C9*1, CYP2C9*2, CYP2C9*3, and CYP2C9*4. In the present study, DNA from 140 European Americans and 120 African Americans was examined by single-strand conformational polymorphism and restriction fragment length polymorphism analyses, resulting in the identification of a ...
L J, Dickmann +7 more
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Forensic Toxicology, 2012
We recently reported that Δ9-tetrahydrocannabinol (Δ9-THC), the primary psychoactive constituent in marijuana, potently inhibits the catalytic activity of cytochrome P450 (CYP) 2C9.1, a wild-type variant. However, effects of CYP2C9 genetic polymorphisms on the inhibitory potency of Δ9-THC have not been investigated.
Satoshi Yamaori +4 more
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We recently reported that Δ9-tetrahydrocannabinol (Δ9-THC), the primary psychoactive constituent in marijuana, potently inhibits the catalytic activity of cytochrome P450 (CYP) 2C9.1, a wild-type variant. However, effects of CYP2C9 genetic polymorphisms on the inhibitory potency of Δ9-THC have not been investigated.
Satoshi Yamaori +4 more
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2014
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???????????????? ???????????? ???????????????????????????? ???????????????????? ?????????????????????? ?????????????????? 430?? > ?? ?? 1075?? > ?? ???????? ?????????????????? ??450 CYP2C9 ?? ?????????????? ?????????????????????? ?????????????????? ?? ?? ?????????????? ???????????????? ?????? ?????????????????? ??????????????????. ????????????????, ????
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CYP2C9 polymorphisms in human tumors.
Anticancer research, 2006The oxazaphosphorines cyclophosphamide (CP) and ifosfamide (IF) are alkylating agents that require bioactivation via cytochrome (CYP) P450 isoenzymes including CYP2C9 enzymes. The present study investigated CYP2C9 in regard to its allelic variants in 23 tumor samples (10 breast tumors, 1 breast tumor cell line, 5 brain tumors, 7 glioma cell lines) with
Heike, Knüpfer +2 more
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Functional impact of CYP2C9*5, CYP2C9*6, CYP2C9*8, and CYP2C9*11 in vivo among black Africans*1
Clinical Pharmacology & Therapeutics, 2004openaire +1 more source
CYP2C9*3, CYP2C9*2 alleles modulate sensitivity to acenocoumarol
Inpharma Weekly, 2002openaire +1 more source