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1996
Publisher Summary This chapter describes methods for the detection of the main CYP2D6 alleles associated with the PM phenotype and discusses the use of single-strand conformational polymorphism (SSCP) analysis and DNA sequencing for the identification of new polymorphisms. The cytochrome P450 enzyme debrisoquine 4-hydroxylase, which is encoded by the
Ann K. Daly +3 more
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Publisher Summary This chapter describes methods for the detection of the main CYP2D6 alleles associated with the PM phenotype and discusses the use of single-strand conformational polymorphism (SSCP) analysis and DNA sequencing for the identification of new polymorphisms. The cytochrome P450 enzyme debrisoquine 4-hydroxylase, which is encoded by the
Ann K. Daly +3 more
openaire +1 more source
IARC scientific publications, 1999
Altered expression of CYP2D6 (debrisoquine hydroxylase), resulting from genetic polymorphism at the CYP2D6 gene locus, is responsible for pronounced interindividual variation in the metabolism of many clinically important drugs. Although CYP2D6 substrates are structurally diverse, most are small molecules that interact with the protein via an ...
Wolf, C R, Smith, G
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Altered expression of CYP2D6 (debrisoquine hydroxylase), resulting from genetic polymorphism at the CYP2D6 gene locus, is responsible for pronounced interindividual variation in the metabolism of many clinically important drugs. Although CYP2D6 substrates are structurally diverse, most are small molecules that interact with the protein via an ...
Wolf, C R, Smith, G
openaire +1 more source
CYP2D6 genetic variation in Ugandans
European Journal of Clinical Pharmacology, 2021Jun Miura +4 more
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