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Pharmacogenomics of CYP2D6, CYP2C19, CYP2C9, and Clinical Determinants of Fluoxetine-Norfluoxetine Pharmacokinetics in Real-World Clinical Conditions. [PDF]

Pharmaceutics
de la Cruz CG, Thomas L, Mata-Martín C, González I, LLerena A, Peñas-Lledó EM.   +5 more
europepmc   +1 more source

CYP2D6-Guided Opioid Management and Postoperative Pain Control: A Randomized Clinical Trial.

JAMA Netw Open
Cavallari LH, Myers RA, Chakraborty H, Skaar TC, Gray CF, Baye JF, Volpi S, Rider R, Cicali EJ, Elwood EN, Harris EC, Hines LJ, Nahid NA, Nguyen KA, Obeng AO, Parr JA, Ramos MA, Orlando LA, Prieto HA, Sadeghpour A, Singh R, Starostik P, Tillman EM, Wyatt C, Horowitz CR, Voora D, Blake KV, Parvataneni HK, Fillingim RB, Dexter PR, Peterson JF, Johnson JA, IGNITE Pragmatic Trials Network.   +32 more
europepmc   +1 more source

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The Impact of the CYP2D6 “Enhancer” Single Nucleotide Polymorphism on CYP2D6 Activity

Clinical Pharmacology & Therapeutics, 2021
rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant “enhancer” single nucleotide polymorphism (SNP), our goal was to further assess the impact of rs5758550 on CYP2D6 activity toward two probe substrates ...
Jean C, Dinh, Erin C, Boone, Vincent S, Staggs, Robin E, Pearce, Wendy Y, Wang, Roger, Gaedigk, James Steven, Leeder, Andrea, Gaedigk   +7 more
openaire   +2 more sources

Induction of CYP2D6 in pregnancy*

Clinical Pharmacology & Therapeutics, 1997
Expression of the drug-metabolizing enzyme cytochrome P4502D6 (CYP2D6) is predominantly under genetic control, and enzyme-inducing drugs have little influence on its activity. We studied the activity of CYP2D6 during pregnancy. One hundred forty pregnant women were genotyped for CYP2D6.
M, Wadelius, E, Darj, G, Frenne, A, Rane
openaire   +2 more sources

Novel single nucleotide polymorphisms in the CYP2D6 gene associated with CYP2D6*2 and/or CYP2D6*10 alleles

Drug Metabolism and Pharmacokinetics, 2002
Novel single nucleotide polymorphisms (SNPs) were found in introns 1, 3, 4, 5, and 7 of the gene encoding cytochrome (CYP) 2D6 in 90 Japanese subjects. Some of these SNPs were associated with C2850T and/or C100T, which are key SNPs for CYP2D6(*)2 and CYP2D6(*)10, respectively.
Akiko, Soyama, Yoshiro, Saito, Kazuo, Komamura, Kazuyuki, Ueno, Shiro, Kamakura, Shogo, Ozawa, Jun-ichi, Sawada   +6 more
openaire   +2 more sources