Results 191 to 200 of about 23,309 (224)

Genetic Polymorphism in Cytochrome P450 2D6 (CYP2D6): Population Distribution of CYP2D6 Activity

Journal of Toxicology and Environmental Health, Part B, 2009
Cytochrome P-450 2D6 (CYP2D6) is involved in the metabolism of many therapeutic drugs even though the enzyme represents a small proportion of the total CYP content of human liver. In vivo phenotyping with probe drug substrates such as debrisoquine and dextromethorphan showed a clear separation between poor metabolizers (PM) and extensive metabolizers ...
Patricia, Neafsey, Gary, Ginsberg, Dale, Hattis, Babasaheb, Sonawane   +3 more
openaire   +2 more sources

MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers

European Journal of Clinical Pharmacology, 2005
(CYP)isoform 2D6 [2]. HHMA is further metabolised to 4-hydroxy, 3-methoxymethamphetamine (HMMA) bycatechol- O-methyltransferase (COMT). HMMA in-duces vasopressin secretion to a higher extent thanMDMA and has been postulated to contribute to hyp-onatraemia observed in some MDMA acute intoxica-tions [4].
Rafael, de la Torre, Magí, Farré, Brian O, Mathúna, Pere N, Roset, Neus, Pizarro, Mireia, Segura, Marta, Torrens, Jordi, Ortuño, Mitona, Pujadas, Jordi, Camí   +9 more
openaire   +2 more sources

Cholic acid feeding increases CYP2D6 expression in CYP2D6‐humanized mice

The FASEB Journal, 2016
Cytochrome P450 (CYP) 2D6 is a major drug‐metabolizing enzyme in the liver, but factors involved in the regulation of CYP2D6 expression remain poorly defined. Recent studies have shown that CYP2D6 expression is repressed by small heterodimer partner (SHP), a transcriptional repressor that is upregulated in cholestasis (1,2).
Rebecca Kent, Xian Pan, Hyunyoung Jeong
openaire   +1 more source

CYP2D6 genetic variation in Ugandans

European Journal of Clinical Pharmacology, 2021
Jun Miura, Celestino Obua, Catherine Abbo, Tomonori Tateishi, Sunao Kaneko   +4 more
openaire   +2 more sources

CYP2D6 genotypes in a Japanese population: low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10

Pharmacogenetics, 2000
Y, Nishida, T, Fukuda, I, Yamamoto, J, Azuma   +3 more
openaire   +2 more sources

CYP2D6-Tamoxifen

Der Gynäkologe, 2010
H. Brauch, W. Schroth
openaire   +1 more source

Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide

Archives of Pharmacal Research, 2020
Jung-Woo Bae, Yun Jeong Lee, Choon-Gon Jang   +2 more
exaly  

CYP2D6 genotyping and codeine

Pediatric Anesthesia, 2008
openaire   +2 more sources

Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone

Archives of Pharmacal Research, 2022
Jung-Woo Bae, Yun Jeong Lee, Choon-Gon Jang   +2 more
exaly  

Interethnic variability ofCYP2D6alleles and of predicted and measured metabolic phenotypes across world populations

Expert Opinion on Drug Metabolism and Toxicology, 2014
Humberto Fariñas, Fernanda Rodrigues-Soares, Addrian Llerena   +2 more
exaly