Results 201 to 210 of about 44,894 (310)

Digital and Biomarker‐Based Monitoring for Schizophrenia‐Treatment Adherence

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Monitoring technologies integrated with artificial intelligence can enable personalized care, improved adherence, and reduced relapses among psychotic patients. ABSTRACT Background Nonadherence to antipsychotics affects nearly half of patients with schizophrenia, leading to rehospitalization, suicidality, and reduced quality of life.
Samuel Inshutiyimana, Kush Rajeshbhai Rana, Michael Matiop Aleu, Naomi Bwalya, Bonaventure Nsengimana, Onesmas Kipkurui   +5 more
wiley   +1 more source

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults - results from the ActiFE study. [PDF]

Eur J Clin Pharmacol
Lorenz L, Berres J, Denkinger MD, Rothenbacher D, Braig S, Dallmeier D, Just KS.   +6 more
europepmc   +1 more source

Codeine and Metabolite Concentrations in the Breastfed Neonate

Pediatric Anesthesia, Volume 36, Issue 9, Page 1016-1022, September 2026.
ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry Quantification of Diet-Derived CYP2D6 Biomarkers for Clinical Phenotyping in Japanese Subjects. [PDF]

Clin Transl Sci
Kumondai M, Hayashi N, Matsumoto Y, Ebata A, Sato M, Harada-Shoji N, Tada H, Miyashita M, Ishida T, Maekawa M, Tomioka Y, Mano N.   +11 more
europepmc   +1 more source

Demographic characteristics and psychosocial backgrounds of patients with dextromethorphan overdose in Japan: A multicenter prospective observational study

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim Few studies in Japan have described young patients presenting to emergency departments after dextromethorphan overdose in detail. Therefore, we aimed to investigate the demographic characteristics and psychosocial backgrounds of patients who presented to emergency departments in Japan after dextromethorphan overdose.
Hironori Katsuki, Yoshito Kamijo, Michiko Takai, Saeko Kohara, Hidetada Fukushima, Yuta Mizuno, Hidenobu Ochiai, Norio Otani, Dai Taguchi, Takuya Shimane, Ryoko Kyan   +10 more
wiley   +1 more source

Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease: Is the Field Ready for Precision Prescribing? [PDF]

J Pers Med
Jaja C, Sop DM, Campbell A, Smith WR.
europepmc   +1 more source

Transitioning from Transcriptomics to Proteomics: Enhancing Mechanistic Accuracy in PBPK Modeling via Absolute Protein Abundances

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Reliable physiologically based pharmacokinetic (PBPK) modeling depends on tissue‐specific expression profiles that reflect protein activities governing drug disposition. In PK‐Sim, existing expression databases rely on transcriptomics data. However, mRNA levels often exhibit limited correlation with protein abundance, frequently necessitating ...
Chen Ning, Alessandra Pugliano, Maximilian Winter, Keliang Wu, Pieter Annaert   +4 more
wiley   +1 more source

Role of the CYP2D6-genpolymorphism for safety and efficiency of CYP2D6 dependently metabolized antidepressants

, 2008
Durch verschiedene CYP2D6-Genmutationen, welche in der Bevölkerung vorkommen, wird bei den betroffenen Personen in der Leber weniger oder kein CYP2D6-Enzym produziert.
Wohlleben, Gerlinde
core  

CYP2D6, Autism, And Oxytocin Receptors

, 2010
Who cares? Differences in oxytocin receptor density have been observed in two brain regions in autism. CNVs of the CYP2D6 gene appear associated with these differences.
Dayley, Ethan
core