Results 41 to 50 of about 49,005 (303)

No association of a set of candidate genes on haloperidol side effects. [PDF]

, 2012
We previously investigated a sample of patients during an active phase of psychosis in the search for genetic predictors of haloperidol induced side effects.
De Ronchi, Diana, Drago, Antonio, Giegling, Ina, Hartmann, Annette M., Möller, Hans-Jürgen, Rujescu, Dan, Schäfer, Martin, Serretti, Alessandro, Stassen, Hans H.   +8 more
core   +4 more sources

The Efficacy of Combination Therapy With SWTX Capsule and Paroxetine for Depression: A Randomized Controlled Trial. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Depression, a leading global cause of disease burden, often shows limited response and notable adverse reactions to existing antidepressants. Exploring combination therapies is therefore crucial to enhance therapeutic efficacy and improve safety.
Fan Y, Sa R, Ma R, Tong L.
europepmc   +2 more sources

Metoclopramide Neurological Side Effects Screening; A Pharmacovigilence Study in Romanian Community Pharmacies [PDF]

, 2015
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics.
Junghină, Adrian, Mireșan, Horațiu, Pleșu, Mihaela, Scutari, Corina, Ștefănescu, Emil   +4 more
core   +4 more sources

Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes

Pharmacology Research & Perspectives, 2022
CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama, Akari Mine, Teppei Nakamura, Yusuke Ohasi, Mayuko Seto, Masako Tada   +5 more
doaj   +1 more source

Mice in ecstasy : advanced animal models in the study of MDMA [PDF]

, 2010
The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy- has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy.
Stove, Christophe, De Letter, Els, Piette, Michel, Lambert, Willy   +3 more
core   +2 more sources

CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. [PDF]

, 2010
INTRODUCTION: Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 gene.
Abraham, Jean E, Baynes, Caroline, Caldas, Carlos, Driver, Kristy E, Dunning, Alison M, Earl, Helena M, Greenberg, David, Ingle, Susan, Kalmyrzaev, Bolot, Luccarini, Craig, Maranian, Mel J, Pharoah, Paul DP, Platte, Radka, Shah, Mitul   +13 more
core   +2 more sources

CYP2D6 pharmacogenomics

Egyptian Journal of Medical Human Genetics, 2017
Cytochromes are proteins that catalyze electron transfer reactions of many metabolic pathways. They are involved in drug metabolism and thus determines the therapeutic safety and efficacy of drugs in patients. Cytochrome P450 in mitochondria accounts for 90% of the oxidative metabolism of clinically used drugs during phase 1 reaction. CYP2D6 is a major
openaire   +3 more sources

Self-Reported Pharmacogenetic Medication Use in the Our Future Health Cohort. [PDF]

Clin Transl Sci
ABSTRACT The aim of this study was to describe self‐reported use of medications with established pharmacogenetic guidance in the Our Future Health (OFH) cohort. We examined four key pharmacogenes—CYP2C19, CYP2C9, CYP2D6, and SLCO1B1—and medications supported by strong evidence for clinical actionability according to the Clinical Pharmacogenetics ...
Dixon P, Newman WG, Sharma V, McDermott JH, Wright Drakesmith C.   +4 more
europepmc   +2 more sources

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update [PDF]

, 2017
CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy and safety of tricyclic antidepressants (TCAs), with some drugs being affected by CYP2D6 only (e.g., nortriptyline and desipramine) and others by both polymorphic enzymes (e.g., amitriptyline,
Bishop, Jeffrey R., Caudle, Kelly E., Dunnenberger, Henry M., Ellingrod, Vicki L., Gaedigk, Andrea, Hicks, J. Kevin, Kharasch, Evan D., Klein, Teri E., Müller, Daniel J., Sangkuhl, Katrin, Shimoda, Kazutaka, Skaar, Todd C., Stingl, Julia C., Swen, Jesse J.   +13 more
core   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source