Results 81 to 90 of about 48,854 (243)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes

Pharmaceutical Biology, 2020
Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang, Bingyan Xia, Mei Lin, Yongpeng Wang, Bin Sun, Yuzhu Li   +5 more
doaj   +1 more source

CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial [PDF]

, 2017
Background Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect
Biasi, Maria Olivia, Bouzyk, Mark, Coates, Alan S., Debled, Marc, Dell'Orto, Patrizia, Ditzel, Henrik J., Gelber, Richard D., Goldhirsch, Aron, Kammler, Roswitha, Leyland-Jones, Brian, Lyng, Maria B., Maibach, Rudolf, Neven, Patrick, Pagani, Olivia, Price, Karen N., Rae, James M., Regan, Meredith M., Tang, Weining, Thürlimann, Beat, Viale, Giuseppe   +19 more
core  

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION

Разработка и регистрация лекарственных средств, 2019
A sensitive method for quantification of pinoline and its metabolite in human plasma using solid phase extraction and high performance liquid chromatography with mass-spectrometry was developed.
R. K. Abdrashitov, A. E. Petukhov, V. V. Smirnov   +2 more
doaj  

Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and O-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling

Pharmaceutics, 2019
Tramadol is a μ-opioid receptor agonist and a monoamine reuptake inhibitor. O-desmethyltramadol (M1), the major active metabolite of tramadol, is produced by CYP2D6.
Hyeon-Cheol Jeong, Soo Hyeon Bae, Jung-Woo Bae, Sooyeun Lee, Anhye Kim, Yoojeong Jang, Kwang-Hee Shin   +6 more
doaj   +1 more source

Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer [PDF]

, 2015
Background Tamoxifen, the most frequently used drug for treating estrogen receptor-positive breast cancer, must be converted into active metabolites to exert its therapeutic efficacy, mainly through CYP2D6 enzymes.
Brewczynska, Elzbieta, Dadlez, Michal, Goryca, Krzysztof, Hennig, Ewa E., Jazwiec, Radoslaw, Karczmarski, Jakub, Kluska, Anna, Omiotek, Robert, Ostrowski, Jerzy, Paziewska, Agnieszka, Piatkowska, Magdalena   +10 more
core   +1 more source

Clinical applications of personalized medicine: a new paradigm and challenge [PDF]

, 2017
The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease.
Borro, Marina, DI SANZO, Mariantonia, Fineschi, Vittorio, Frati, Paola, LA RUSSA, Raffaele, Santurro, Alessandro, Scopetti, Matteo, Simmaco, Maurizio   +7 more
core   +1 more source

Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol [PDF]

, 2020
Ragnhild Birkeland Waade, Vigdis Solhaug, Gudrun Høiseth   +2 more
openalex   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia [version 3; peer review: 2 approved]

F1000Research
Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs.
Nuruliawaty Utami, Bagus Dermawan, Asrul Muhammad Fuad, Aufa Rizqia Haz, Rinal Effendi, . Desriani   +5 more
doaj   +1 more source

Characterization of hepatic enzyme activity in older adults with dementia: potential impact on personalizing pharmacotherapy [PDF]

, 2015
OBJECTIVE: To determine the frequency of pharmacogenomic variants and concurrent medications that may alter the efficacy and tolerability of acetylcholinesterase inhibitors (AChEIs).
Boustani, Malaz A., Campbell, Noll L., Gao, Sujuan, Khan, Babar A., Li, Lang, Perkins, Anthony J., Skaar, Todd C.   +6 more
core   +2 more sources