Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro [PDF]
Frontiers in Pharmacology, 2019 Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment.
Xiao-Yang Zhou +7 more
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CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?
Frontiers in Genetics, 2021 Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs.
Tessa A. M. Mulder +12 more
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Functional assessment of CYP3A4 allelic variants on lidocaine metabolism in vitro
Drug Design, Development and Therapy, 2017 Ping Fang,1 Peng-fei Tang,1 Ren-ai Xu,2 Xiang Zheng,1 Jian Wen,1 Su-su Bao,1 Jian-ping Cai,3 Guo-xin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, 2Department of Pharmacy, The First Affiliated Hospital of Wenzhou ...
Fang P +7 more
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Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin [PDF]
Molecular Pharmacology, 2017 Yan Liang +6 more
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"Reconsidering CYP3A4/5 Genotyping for Ticagrelor Safety: Critical Appraisal of a Narrow Genetic Framework". [PDF]
Clin CardiolTahir I, Shahbaz H.
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PLoS ONE, 2014 Tacrolimus is a widely used immunosuppressive drug for preventing the rejection of solid organ transplants. The efficacy of tacrolimus shows considerable variability, which might be related to genetic variation among recipients.
Chuanjiang Li +9 more
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The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?
International Journal of Molecular Sciences, 2022 Ritonavir is the most potent cytochrome P450 (CYP) 3A4 inhibitor in clinical use and is often applied as a booster for drugs with low oral bioavailability due to CYP3A4-mediated biotransformation, as in the treatment of HIV (e.g., lopinavir/ritonavir ...
N. Loos, J. Beijnen, A. Schinkel
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Hepatitis C virus infection: Epidemiology in Egypt, Pathophysiology and DAAs-based therapy
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Hepatitis C virus (HCV) was first identified in 1989. The situation in Egypt is really dire. The prevalence of HCV genotype 4 (GT-4) is 14.7%. About 10% of the middle-aged population (ages 15 to 59) is infected with HCV.
Heba Elbadawy +2 more
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SLCO1B1 and CYP3A4 allelic variants associated with pharmacokinetic interactions and adverse reactions induced by simvastatin and atorvastatin used in Peru: Clinical implications [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Statins reduce the risk of stroke and prevent cardiac events in people with atherosclerosis and diabetes mellitus; and could affect the proliferation, migration, and survival of cancer cells.
Angel T. Alvarado +16 more
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Drug Metabolism And Disposition, 2023 Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs.
Fengling Wang +7 more
semanticscholar +1 more source