Results 111 to 120 of about 61,480 (319)

The Chinese-Han Population Carrying Wild-type Genotypes of SLCO1B1 388A>G, SLCO1B1 521T>C, CYP3A4 1B, CYP3A4 1G, and CYP3A5*3 Exhibits a Significant Alteration in the Pharmacokinetics of Atorvastatin Calcium

, 2023
Binbin Xia, Xianjun Liu, Yali Li, Yang Liu, Wenfang Sun, Jing Chen, Liushui Li, Jingyao Pang, Shicai Chen, Hua Cheng   +9 more
openalex   +2 more sources

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Половые различия в биотрансформации лекарственных средств: значение для проведения клинических исследований лекарственных средств

Фармакокинетика и Фармакодинамика, 2020
Долгое время клинические исследования лекарственных средств I и II фазы у женщин не проводились, что было связано с опасениями негативного воздействия на возможную беременность и плод.

doaj  

In vitro inhibitory effects of bergenin on human liver cytochrome P450 enzymes

Pharmaceutical Biology, 2018
Context: Bergenin, isolated from the herb of Bergenia purpurascens (Hook. f. et Thoms.) Engl., has anti-inflammatory, antitussive, and wound healing activities.
Gang Dong, Yun Zhou, Xiaoli Song
doaj   +1 more source

Comparison of Steroid Hormone Hydroxylations by and Docking to Human Cytochromes P450 3A4 and 3A5

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (P450 or CYP) 3A4 and CYP3A5 and their molecular docking energy values were compared to understand the catalytic ...
Toshiro Niwa, Kanae Narita, Ayaka Okamoto, Norie Murayama, Hiroshi Yamazaki   +4 more
doaj   +1 more source

A Novel Multiplex PCR-RFLP Method for Simultaneous Genotyping of CYP3A4*4 A>G, CYP3A4*18B G>A and CYP3A4*22 C>T

Malaysian Journal of Medical Sciences, 2018
Cytochrome P450 3A enzymes exhibit a variety of physiological roles and have been reported to be the most predominant enzymes involved in drugs metabolism. Single nucleotide polymorphisms (SNPs) in the genes that code for these enzymes may result in functional changes that affect enzyme activity.
Abubakar, Murtala Bello, Tan, Huay Lin, Gan, Siew Hua   +2 more
openaire   +2 more sources

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

CYP3A4 Polymorphisms and Acute Cellular Rejection in Lung Transplant Patients

, 2021
A. Terravecchia, Amber L. Beitelshees, Dimitrius Vidal de Oliveira Garbis, Roumen Vesselinov, Ashu Gandhi, Nicholas Ladikos, Aldo Iacono, Si M. Pham, I. Timofte   +8 more
openalex   +1 more source

Effect of CYP3A4*22, CYP3A5*3, and CYP3A Combined Genotypes on Cyclosporine, Everolimus, and Tacrolimus Pharmacokinetics in Renal Transplantation

CPT: Pharmacometrics & Systems Pharmacology, 2014
Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive therapy in renal transplantation. These drugs are characterized by narrow therapeutic windows, highly variable pharmacokinetics (PK), and metabolism by CYP3A enzymes ...
D. Moes, J. Swen, J. Hartigh, T. Straaten, JJ Homan Heide, J. Sanders, FJ Bemelman, J. Fijter, H. Guchelaar   +8 more
semanticscholar   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source