Results 171 to 180 of about 61,480 (319)

Lipid Dependence of CYP3A4 Activity in Nanodiscs. [PDF]

Biology (Basel)
Denisov IG, Grinkova YV, Sligar SG.
europepmc   +1 more source

932 Prolonged Midazolam Clearance and CYP3A4 Genetic Variants in a 4-year-old Pediatric Burn Patient [PDF]

Kristin Grimsrud, Tina L. Palmieri
openalex   +1 more source

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC–HRMS/MS, Molecular Docking, and ADMET Analysis

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study investigates the phytochemical composition and biological activities of a hydroalcoholic extract of Haloxylon articulatum. LC‐HRMS/MS identified diverse bioactive compounds, notably N‐caffeoyltyramine and sinapoyltyramine. The extract exhibited strong antioxidant activity and significant cytotoxic effects against gastric cancer cell lines ...
Jihen Abidi, Amal Ben Hassena, Rania Ben Hmida, Łukasz Kulinowski, Erdi Can Aytar, Reyedh R. Al‐Rashidi, Mohamed Bouaziz   +6 more
wiley   +1 more source

New Insights into Prostate Cancer Susceptibility in European Caucasians: A Systematic Review and Meta-Analysis of CYP3A4 Pharmacogene. [PDF]

Cancers (Basel)
Pagoni M, Cava C, Tsangaris GT, Siannis F, Drakoulis N.   +4 more
europepmc   +1 more source

Minor Contribution of UGT1A1 Inhibition to Atazanavir‐Related Bilirubin Elevation Supported by Conservative PBPK Modeling and Clinical Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 583-586, March 2026.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals.
Rahim Badrfam, Atefeh Zandifar
wiley   +1 more source

Molecular dynamics simulations elucidate the role of the F-F' loop in substrate entry into CYP3A4. [PDF]

Commun Chem
Yan J, Hirao H.
europepmc   +1 more source

Influence of Cytochrome P450 (CYP) <i>3A4*1G</i> Polymorphism on the Pharmacokinetics of Tacrolimus, Probability of Acute Cellular Rejection, and mRNA Expression Level of CYP3A5 Rather than CYP3A4 in Living-Donor Liver Transplant Patients

, 2013
Miwa Uesugi, Mio Hosokawa, Haruka Shinke, Emina Hashimoto, Tamotsu Takahashi, Tomoki Kawai, Kazuo Matsubara, Kohei Ogawa, Yasuhiro Fujimoto, Shinya Okamoto, Toshimi Kaido, Shinji Üemoto, Satohiro Masuda   +12 more
openalex   +2 more sources

Review of grapefruit juice-drugs interactions mediated by intestinal CYP3A4 inhibition [PDF]

, 2014
Wael Abu Dayyih, Israa Al Ani, Mohammad Hailat, Samia M. Alarman, Zainab Zakaraya, Mohammad Abu Assab, Enas Alkhader   +6 more
openalex   +1 more source

Omeprazole Induces CYP3A4 mRNA Expression but Not CYP3A4 Protein Expression in HepaRG Cells.

Biological & pharmaceutical bulletin
Unknown interactions between drugs remain the limiting factor for clinical application of drugs, and the induction and inhibition of drug-metabolizing CYP enzymes are considered the key to examining the drug-drug interaction (DDI). In this study, using human HepaRG cells as an in vitro model system, we analyzed the potential DDI based on the expression
Yuto, Fujita, Takahito, Miyake, Xinyan, Shao, Yuto, Aoki, Emi, Hasegawa, Masao, Doi   +5 more
openaire   +1 more source