Results 221 to 230 of about 61,480 (319)

Specifics of drug-drug interactions between rivaroxaban and a P-glycoprotein inhibitor depending on the <i>CYP3A4/A5</i> gene polymorphism in patients aged 80 years and older with non-valvular atrial fibrillation

М. С. Черняева, Irena Konstantinova, E. I. Baranovskaya, О. В. Головина, I. I. Sinitcina, П. О. Бочков, Sh. P. Abdullaev, Н. П. Денисенко, G. A. Sozaeva, К. Б. Мирзаев, N. V. Lomakin, Д. А. Сычев   +11 more
openalex   +2 more sources

Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit.

British Journal of Clinical Pharmacology, 2015
Hylke de Jonge, T. Vanhove, H. de Loor, K. Verbeke, D. Kuypers   +4 more
semanticscholar   +1 more source

Development of a Physiologically Based Model of Bilirubin Metabolism in Health and Disease and Its Comparison With Real‐World Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Ahenk Zeynep Sayin, Lars Kuepfer
wiley   +1 more source

In vitro and clinical data demonstrate negligible risk of drug-drug interactions with opelconazole, a novel inhaled antifungal agent. [PDF]

J Antimicrob Chemother
Cass LMR, Ayrton J, Brüggemann RJ, Moore J, Martin U, Grey L, Hyman M, Berman L.   +7 more
europepmc   +1 more source

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source

The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma [PDF]

, 2017
Qixing Mao, Xu Juqing, Yajing Wang, Gaochao Dong, Wenjie Xia, Shi Run, Wang Anpeng, Lin Xu, Feng Jiang, Jun Wang   +9 more
openalex   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

Baicalin protects against heat-induced multiorgan dysfunction <i>via</i> organ-specific protein modulation: integrative <i>in silico</i> and <i>in vivo</i> evidence. [PDF]

RSC Adv
Kumari A, Tufail A, Abdellattif MH, Dubey A, Sinha RK.   +4 more
europepmc   +1 more source

Prediction of the site of CYP3A4 metabolism of tolterodine by molecular dynamics simulation from multiple initial structures of the CYP3A4-tolterodine complex

, 2017
Atsuko Sato, Hitomi Yuki, Chiduru Watanabe, Junichi Saito, Akihiko Konagaya, Teruki Honma   +5 more
openalex   +2 more sources

Antiseizure Effects of Cannabidiol in Combination With Cannabigerol in the Maximal Electroshock Seizure Model

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.
Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Han Zhong Zhou, Brian Wayne Scott, Yagoda Izabela Oleksak, Willets McIntyre Burnham   +3 more
wiley   +1 more source