Results 31 to 40 of about 4,157 (190)

Kajian Pengaruh Polimorfisme CYP4F2 rs2108622 terhadap Pemberian Dosis Warfarin

Jurnal Riset Farmasi, 2022
Abstract. Warfarin is an oral anticoagulant drug indicated for the treatment of thromboembolism. Warfarin has a narrow therapeutic index, so care must be taken in determining the dose of warfarin for the patient. The effect of anticoagulant therapy produced by warfarin in individuals may vary due to the influence of the CYP4F2 polymorphism rs2108622 ...
null Muhammad Adliansyah Prawiratama Hidayat, null Miswar Fattah   +1 more
openaire   +1 more source

Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]

, 2013
Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
core   +4 more sources

Genetic polymorphisms in CYP4F2 may be associated with lung cancer risk among females and no-smoking Chinese population

Frontiers in Oncology, 2023
BackgroundOur study aimed to explore the potential association of CYP4F2 gene polymorphisms with lung cancer (LC) risk.MethodsThe five variants in CYP4F2 were genotyped using Agena MassARRAY in 507 cases and 505 controls.
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu   +4 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update [PDF]

, 2017
This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing.
Anderson, JL, Caudle, KE, Cavallari, LH, Gage, BF, Gong, L, Johnson, JA, Kimmel, SE, Klein, TE, Lee, MT, Limdi, NA, Perera, MA, Pirmohamed, M, Scott, SA, Stein, CM, Wadelius, M, Whirl-Carrillo, M   +15 more
core   +1 more source

Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population

PLoS ONE, 2023
High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE ...
Lining Si, Haiyuan Wang, Rong Wang, Lhachen Tsering, Qifu Long, Yahui Jiang, Yun Yi, Yanli Zhao   +7 more
doaj   +2 more sources

Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.

PLoS ONE, 2014
Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy.
Shaminie Athinarayanan, Rongrong Wei, Min Zhang, Shaochun Bai, Maret G Traber, Katherine Yates, Oscar W Cummings, Jean Molleston, Wanqing Liu, Naga Chalasani   +9 more
doaj   +1 more source

A multi-factorial analysis of response to warfarin in a UK prospective cohort [PDF]

, 2016
Background Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response.
A Holbrook, A Rouaud, AE Rettie, AH Maitland-van der Zee, AK Hamberg, AL Jorgensen, AL Jorgensen, Andrea Jorgensen, Anita Hanson, Ann K. Daly, AR Tabrizi, BN Howie, BS Finkelman, C Barnes, Cheng Hock Toh, DR Plowchalk, Eunice J. Zhang, F Takeuchi, F Xu, Farhad Kamali, G D’Andrea, GP Aithal, H Furuya, HY Yuan, J Marchini, JB Saunders, L Poller, M Connock, M Ohara, M Pirmohamed, M Pirmohamed, M Wadelius, M Wadelius, M Wadelius, M Wadelius, MA Crowther, Matthew S. Gillman, MD Caldwell, MI Aguilar, MJ Rieder, MT Lee, Munir Pirmohamed, NA Limdi, P Lenzini, Panos Deloukas, Paula Williamson, PJ Avery, R Loebstein, S Purcell, SE Kimmel, SK Ganesh, Stephane Bourgeois, Suzannah Bumpstead, VC Oliveira Almeida de, WE Nostrand Van, YY Teo   +55 more
core   +3 more sources

Pleiotropic Effects of Ticagrelor: Influence on CYP4F2 Gene and Protein Expression in HUVEC and HepG2, and Escherichia coli Bacterial Survival

Drug Design, Development and Therapy, 2022
Ugne Meskauskaite,1 Silvija Andruskeviciute,1 Ieva Ciapiene,1 Agne Giedraitiene,2 Vaiva Lesauskaite,1 Vacis Tatarunas1 1Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Institute of Microbiology and Virology ...
Meskauskaite U, Andruskeviciute S, Ciapiene I, Giedraitiene A, Lesauskaite V, Tatarunas V   +5 more
doaj  

Frequencies of polymorphisms in genes affecting the pharmacokinetics of warfarin in the Zaporizhzhia region

Zaporožskij Medicinskij Žurnal, 2021
The aim of the study: to establish the frequencies of polymorphisms in VKORC1, CYP2C9 and CYP4F2 genes among residents of the Zaporizhzhia region. Materials and methods. A total of 150 persons (62 male, 88 female) with a median age of 46 years (26; 58)
M. Yu. Kolesnik, Yа. М. Mykhailovskyi
doaj   +1 more source

CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke

Genetics and Molecular Research, 2015
The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene.
H-Q, Yan, Y, Yuan, P, Zhang, Z, Huang, L, Chang, Y-K, Gui   +5 more
openaire   +2 more sources