Results 91 to 100 of about 34,415 (185)

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

AMPK:an energy-sensing pathway with multiple inputs and outputs [PDF]

, 2016
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide-dependent mechanism that activates AMPK when cellular energy status is compromised, as ...
Banko, Baur, Behrends, Blethrow, Calabrese, Carling, Chen, Chen, Cool, Corton, Crooks, Crute, Dale, Davies, DeRan, Ducommun, Egan, Fogarty, Gomez-Galeno, Goodwin, Goransson, Gowans, Grant, Gwinn, Habelhah, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Hoffman, Huang, Hudson, Hunter, Hurley, Huttlin, Istvan, Lai, Langendorf, Lee, Li, Marin, Michell, Mihaylova, Mitchelhill, Oakhill, Oakhill, Obenauer, Pang, Pirkmajer, Polekhina, Racanelli, Riek, Sanders, Schaffer, Scott, Scott, Shah, Songyang, Taylor, Tuerk, Tuerk, Weekes, Woods, Xiao, Xiao, Xiao, Xin, Yaffe, Zhang, Zhang   +72 more
core   +2 more sources

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Hydrogen sulfide regulates insulin secretion and insulin resistance in diabetes mellitus, a new promising target for diabetes mellitus treatment? A review

Journal of Advanced Research, 2021
Background: Insulin resistance and impaired insulin secretion lead to disorders of glucose metabolism, which contributes to the development of diabetes.
Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin   +6 more
doaj   +1 more source

내흉동맥과 요골동맥의 황화수소 합성효소의 발현 양상 비교 분석: 관상동맥우회도관으로서 미치는 영향 [PDF]

, 2022
학위논문(박사) -- 서울대학교대학원 : 의과대학 의학과, 2022. 8. 김웅한.Objectives: The molecular basis supporting the superiority of the left internal thoracic artery (LITA) as a bypass conduit is limited.
강윤진
core  

Reaction of carbon monoxide with cystathionine β-synthase: implications on drug efficacies in cancer chemotherapy.

Future Medicinal Chemistry, 2020
Photo-activatable carbon monoxide (CO)-releasing molecules (photoCORMs), have recently provided help to identify the salutary effects of CO in human pathophysiology.
Brian Kawahara, S. Sen, P. Mascharak
semanticscholar   +1 more source

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, EarlyView.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Targeting Glutathione and Cystathionine β-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation

Nutrients, 2019
Ovarian cancer is the main cause of death from gynecological cancer, with its poor prognosis mainly related to late diagnosis and chemoresistance (acquired or intrinsic) to conventional alkylating and reactive oxygen species (ROS)-generating drugs.
Inês Santos, C. Ramos, Cindy Mendes, C. Sequeira, C. S. Tomé, D. G. Fernandes, Pedro Mota, Rita F. Pires, Donato Urso, Ana Hipólito, A. Antunes, João B Vicente, S. Pereira, V. Bonifácio, Sofia C. Nunes, J. Serpa   +15 more
semanticscholar   +1 more source

OsPT4 Facilitates Selenomethionine Transport and Biosynthesis to Enhance Seed Accumulation in Rice: Molecular Mechanisms and Biotechnological Potential

Plant Biotechnology Journal, EarlyView.
ABSTRACT Selenium (Se) is a vital micronutrient for humans, with important functions for health and anti‐cancer properties. Organic Se shows higher antioxidant activity and much lower toxicity compared to inorganic Se, making it safer for use. Selenomethionine (SeMet) is one of the primary forms of organic Se.
Yang Yang, Lijuan Sun, Jia Wei, Fang Zhang, Shiyan Yang, Jiarui Zhang, Qin Qin, Jun Wang, Guohua Xu, Shubin Sun, Yafei Sun, Yong Xue   +11 more
wiley   +1 more source

Changes in serine metabolism by a serum factor present in a group of episodic psychotic patients [PDF]

, 1991
__Abstract__ Addition of serum, obtained from patients suffering from an acute psychosis characterized by dysperceptions, to the culture media of fibroblasts altered the amino acid metabolism in these cells.
Bruinvels, J., Fekkes, D. (Durk), Pepplinkhuizen, L. (Lolke)   +2 more
core   +1 more source