Results 81 to 90 of about 1,104,559 (168)

Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]

, 2018
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Rosario Vallone, Paola Dominici, Janson, Giacomo, Dominici, Paola, Elena Maresi, Maresi E, Astegno, Alessandra, VALLONE, ROBERTO, Fruncillo S, Paiardini, Alessandro, Vallone, Rosario, Astegno A., Maresi, Elena, Alessandro Paiardini, Janson G, FRUNCILLO, SILVIA, Giacomo Janson, Silvia Fruncillo, Alessandra Astegno, Paiardini A, Dominici P   +20 more
core   +1 more source

Role of Hydrogen Sulfide in the Pathology of Inflammation

Scientifica, 2012
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase.
Madhav Bhatia
doaj   +1 more source

High Prevalence of the I278T Mutation of the Human Cystathionine β-Synthase Detected by a Novel Screening Application

, 2001
SummaryClassical homocystinuria due to cystathionine beta-synthase deficiency is one of the disorders revealing a high risk of thromboembolic events and vascular disease.
Ralf Junker, Erik Harms, Anja Homberger, Ulrike Nowak-Goettl, Hans Koch, Michael Linnebank   +5 more
core   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2374-2380, October 2026.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

, 2015
Oxidative stress plays an important role in cardiovascular diseases. The study investigated the effects of dietary palm tocotrienol-rich fraction on homocysteine metabolism in rats fed a high-methionine diet.
Nonan, Mohd Rizal, Ayob, Azizi, Kamisah, Yusof, Othman, Faizah, Ku Zaifah, Norsidah, Ahmad Yusof, Asmadi, Asmadi, Ahmad Yusof   +6 more
core  

Loss of the Protein Cystathionine β-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis

Kidney & Blood Pressure Research, 2017
Background/Aims: Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF.
Xiangning Yuan, Jin Zhang, Feifei Xie, Wenqing Tan, Shuting Wang, Ling Huang, Lijian Tao, Qiqi Xing, Qiongjing Yuan   +8 more
doaj   +1 more source

Two siblings with vitamin B6-nonresponsive cystathionine β-synthase deficiency and differing blood methionine levels during the neonatal period [PDF]

, 1997
We present two siblings with vitamin B6-nonresponsive homocystinuria due to a deficiency of cystathionine β-synthase who had different levels of methionine in the blood during the neonatal period, even though they had the same genetic defect. One of them
Naito, Etsuo, Watanabe, Toshiyuki, Ito, Michinori, マツダ, ジュンコ, Yokota, Ichiro, 1153, クロダ, ヤスヒロ, ワタナベ, トシユキ, ナイトウ, エツオ, 黒田, 弘, 60666/profile-ja.html, Kuroda, Yasuhiro, イトウ, ミチノリ, ヨコタ, イチロウ, Matsuda, Junko   +14 more
core  

Cystathionine β-synthase 844ins68 Genetic Polymorphism in Spontaneous Abortion Susceptibility

Applied Medical Informatics, 2011
Aim: Genetic polymorphisms in homocysteine-related genes are subject of a large body of research in pregnancy and newborn associated pathologies. The enzyme cystationine β-synthase (CBS) is involved in the transsulfuration pathway of homocysteine to ...
Radu Anghel POPP, Tania Octavia CRIŞAN, Ioana ROTAR, Marius Florin FARCAŞ, Adrian Pavel TRIFA, Mariela Sanda MILITARU, Ioan Victor POP   +6 more
doaj  

A Rapid Screening Method for the Measurement of Neonatal Total Homocysteine in Dried Blood Spots by Liquid Chromatography-Tandem Mass Spectrometry

International Journal of Neonatal Screening, 2017
Homocystinuria (HCU) due to cystathionine-β-synthase deficiency is generally regarded as a rare disease, but within the Qatari population has an incidence of 1 in 1800 live births. Most newborn screening methods for HCU using dried blood spots (DBS) rely
Rose Maase, Victor Skrinska, Noura Younes, Lubna Hassan, Rola Mitri, Dietrich Matern, Piero Rinaldo, Coleman Turgeon   +7 more
doaj   +1 more source