Results 91 to 100 of about 1,104,559 (168)

Hydrogen sulfide reduces oxidative stress in Huntington’s disease via Nrf2

Neural Regeneration Research
The pathophysiology of Huntington’s disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic
Zige Jiang, Dexiang Liu, Tingting Li, Chengcheng Gai, Danqing Xin, Yijing Zhao, Yan Song, Yahong Cheng, Tong Li, Zhen Wang   +9 more
doaj   +1 more source

Published Interactions of the Gasotransmitters.

, 2015
HO heme oxygenase; CSE cystathionine-γ-lyase; CBS cystathionine-β-synthase; NOS nitric oxide synthase (eNOS endothelial isoform, iNOS inducible isoform, nNOS neuronal isoform).
Grazyna Chwatko (615334), Hannah K. Palliser (615332), Megan A. Kelly (453438), Rebecca M. Dyson (615331), Rafal Glowacki (615335), Joanna L. Latter (615333), Ian M. R. Wright (615336)   +6 more
core   +1 more source

Factor V Leiden mutation in Turkish patients with homozygous cystathionine β‐synthase deficiency

, 2001
Venous and arterial thromboembolism can occur in patients with homocystinuria. Resistance to activated protein C, which is caused by a single point mutation in the gene for factor V, renders an individual at risk for thrombosis.
Aydodu, S.D., A. Tokatli, T. Coşkun, S. D. Aydoğdu, H. S. Kalkanoğlu, GÜRGEY, AYTEMİZ, TOKATLI, AYŞEGÜL, Kalkanolu, H.S., Cokun, T., A. Gürgey   +9 more
core   +1 more source

Disease-causing cystathionine β-synthase linker mutations impair allosteric regulation. [PDF]

J Biol Chem, 2023
Roman JV, Mascarenhas R, Ceric K, Ballou DP, Banerjee R.   +4 more
europepmc   +1 more source

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H₂S Systems

Biomolecules
Early life stress (ELS) significantly increases the risk of chronic cardiovascular diseases and may cause neuroinflammation. This post hoc study, based on the material available from a previous study showing elevated “serum brain injury markers” in male ...
Franziska Münz, Nadja Abele, Fabian Zink, Eva-Maria Wolfschmitt, Melanie Hogg, Claus Barck, Josef Anetzberger, Andrea Hoffmann, Michael Gröger, Enrico Calzia, Christiane Waller, Peter Radermacher, Tamara Merz   +12 more
doaj   +1 more source

A role for the cystathionine-β-synthase /H₂S axis in astrocyte dysfunction in the aging brain. [PDF]

Redox Biol, 2023
Dey A, Pramanik PK, Dwivedi SKD, Neizer-Ashun F, Kiss T, Ganguly A, Rice H, Mukherjee P, Xu C, Ahmad M, Csiszar A, Bhattacharya R.   +11 more
europepmc   +1 more source

Hydrogen sulfide and its role in female reproduction

Frontiers in Veterinary Science
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Aneta Pilsova, Zuzana Pilsova, Barbora Klusackova, Natalie Zelenkova, Eva Chmelikova, Pavla Postlerova, Marketa Sedmikova   +6 more
doaj   +1 more source

Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells. [PDF]

Front Oncol, 2023
Liskova V, Chovancova B, Babula P, Rezuchova I, Pavlov KP, Matuskova M, Krizanova O.   +6 more
europepmc   +1 more source

Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

Communications Biology
There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target.
J. Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang   +12 more
doaj   +1 more source

The Structure and Nucleotide-Binding Characteristics of Regulated Cystathionine β-Synthase Domain-Containing Pyrophosphatase without One Catalytic Domain. [PDF]

Int J Mol Sci, 2023
Zamakhov IM, Anashkin VA, Moiseenko AV, Orlov VN, Vorobyeva NN, Sokolova OS, Baykov AA.   +6 more
europepmc   +1 more source