Results 61 to 70 of about 1,104,559 (168)

Cross‐species transcriptomics uncovers shared responses to water deficiency in plants

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Deepening our knowledge of conserved molecular mechanisms governing stress responses in plants is fundamental for identifying new core genes and processes involved in tolerance to adverse environmental conditions. For this purpose, we developed a bioinformatic pipeline to retrieve and integrate stress‐related RNA‐seq transcriptomic data from ...
Francesco Punzi, Diana Lucia Zuluaga, Qiao Wen Tan, Marek Mutwil, Gabriella Sonnante, Pasquale Luca Curci   +5 more
wiley   +1 more source

Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction

Scientific Reports, 2022
Persulfidation contributes to a group of redox post-translational modifications (PTMs), which arise exclusively on the sulfhydryl group of cysteine as a result of hydrogen sulfide (H2S) action.
Hedvika Řimnáčová, Jiří Moravec, Miriama Štiavnická, Jiřina Havránková, Ladan Monsef, Petr Hošek, Šárka Prokešová, Tereza Žalmanová, Tereza Fenclová, Jaroslav Petr, Milena Králíčková, Jan Nevoral   +11 more
doaj   +1 more source

Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Nutritional therapy is critical in managing inherited metabolic diseases (IMDs), and includes specialized diets and single nutritional therapy products (sNTPs) such as vitamins, cofactors, and amino acids. Many sNTPs function as medicines, but are regulated as food (e.g., food supplements), which can limit access, reimbursement, and consistent
Nina N. Stolwijk, Bart M. F. Penninx, Annet M. Bosch, Mirjam Langeveld, Gajja S. Salomons, Carla E. M. Hollak, Essential Nutritional Therapy Products for IMDs Consensus Group, Dorothea Möslinger, Saskia Wortmann, David Cassiman, Pavel Ješina, Jiri Zeman, Allan M. Lund, François Feillet, Nazi Tabatadze, Sarah C. Grünert, Anke Schumann, Ute Spiekerkoetter, Ulrike Mütze, Thomas Opladen, Anastasia Skouma, Ina Knerr, Serena Gasperini, Vincenza Gragnaniello, Mariarosa (Marina) Anna Beatrice Melone, Francesca Nardecchia, Alessandro La Rosa, Birutė Tumienė, Margreet Wagenmakers, Terry Derks, Camilla Tøndel, Beata Kieć‐Wilk, Urh Groselj, Amaya Bélanger‐Quintana, Javier De las Heras, Mireia del Toro Riera, Eva Venegas Moreno, Matthias Gautschi, Johannes Häberle, Elaine Murphy   +39 more
wiley   +1 more source

Normal taurine synthesis in cystathionine beta-synthase knockout mice.

, 2004
Normal taurine synthesis in cystathionine beta-synthase knockout ...
Wei-Hsun. Chao (7982912)
core   +3 more sources

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase

, 2010
The catalytic potential for H 2 S biogenesis and homocysteine clearance converge at the active site of cystathionine β-synthase (CBS), a pyridoxal phosphate-dependent enzyme.
Janet L. Smith, Markos Koutmos, Omer Kabil, Ruma Banerjee   +3 more
core   +1 more source

CYSTATHIONINE β-SYNTHASE DEFICIENCY: METABOLIC ASPECTS [PDF]

, 1997
Cystathionine β-synthase (CBS) deficiency was first demonstrated in 1964 in an eight-year-old mentally retarded girl with bilaterally dislocated optic lenses who excreted abnormally elevated amounts of homocystine in her urine.
Mudd, S. Harvey, S. Harvey Mudd
core   +1 more source

Characterization and Crystal Structure Elucidation of the l‐Homoserine O‐Succinyltransferase MetXS From Cupriavidus necator H16

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This study reports the identification, heterologous production, and in vitro characterization of the homoserine O‐succinyltransferase from C. necator (CnMetXS). Several biochemical parameters, including the pH and temperature optima, thermostability, substrate scope, and kinetic parameters, are determined, and a high‐resolution X‐ray structure of ...
Hannah Pia Franziska Meier, Rick Oerlemans, Henrik Terholsen, Matthew R. Groves, Lars Lauterbach, Sandy Schmidt   +5 more
wiley   +1 more source

Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley   +1 more source

Characterization of the Heme in Human Cystathionine β-Synthase by X-ray Absorption and Electron Paramagnetic Resonance Spectroscopies^†

, 2016
Human cystathionine β-synthase is one of two key enzymes involved in intracellular metabolism of homocysteine. It catalyzes a β-replacement reaction in which the thiolate of homocysteine replaces the hydroxyl group of serine to give the product ...
Jungwon Hwang (2945127), James E. Penner-Hahn (1518652), Ruma Banerjee (45954), Ömer Kabil (2945124), Sunil Ojha (32679)   +4 more
core   +1 more source

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source