Results 1 to 10 of about 7,504 (137)

Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction [PDF]

Redox Biology, 2022
Hydrogen sulfide (H2S), produced by cystathionine γ lyase (CSE), is an important endogenous gasotransmitter to maintain heart function. However, the molecular mechanism for how H2S influences the mitochondrial morphology during heart failure remains ...
Dan Wu, Bo Tan, Yuanyuan Sun, Qingxun Hu
doaj   +2 more sources

Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation [PDF]

Scientific Reports, 2023
D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS).
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano   +18 more
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6-Bromoindole- and 6-Bromoindazole-Based Inhibitors of Bacterial Cystathionine γ-Lyase Containing 3-Aminothiophene-2-Carboxylate Moiety [PDF]

Molecules
In recent years, a number of synthetic potentiators of antibiotics have been discovered. Their action can significantly enhance the antibacterial effect and limit the spread of antibiotic resistance through inhibition of bacterial cystathionine-γ-lyase ...
Roman A. Novikov, Dmitry N. Platonov, Alexander Yu. Belyy, Konstantin V. Potapov, Maxim A. Novikov, Yury V. Tomilov, Olga I. Kechko, Tatiana A. Seregina, Anastasia S. Zemskaya, Pavel N. Solyev, Vladimir A. Mitkevich   +10 more
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Synthesis of the Indole-Based Inhibitors of Bacterial Cystathionine γ-Lyase NL1-NL3 [PDF]

Molecules, 2023
Bacterial cystathionine γ-lyase (bCSE) is the main producer of H2S in pathogenic bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, etc.
Konstantin V. Potapov, Roman A. Novikov, Maxim A. Novikov, Pavel N. Solyev, Yury V. Tomilov, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich   +7 more
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Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization [PDF]

JVS - Vascular Science, 2023
Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease ...
Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD   +12 more
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Cystathionine γ-lyase downregulation promotes liver injury and necroptosis through reprogramming of methionine cycle [PDF]

Redox Report
Objective Chronic liver diseases (CLDs) are prevalent globally. The purpose of the current study was to elucidate the regulatory mechanisms underlying the pathophysiological processes in CLDs.Methods and Results Using the GEO database, we identified ...
Cichun Wu, Wei Zhang, Wenhu Liu, Zhengshan Tang, Shifang Peng, Lei Fu, Xin Ni   +6 more
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Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa [PDF]

Scientific Reports
The escalating drug resistance among microorganisms underscores the urgent need for innovative therapeutic strategies and a comprehensive understanding of bacteria's defense mechanisms against oxidative stress and antibiotics.
Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz   +11 more
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Sulfur Amino Acid Metabolism and the Role of Endogenous Cystathionine-γ-lyase/H₂S in Holstein Cows with Clinical Mastitis [PDF]

Animals, 2022
H2S plays an important role in various inflammatory diseases. However, the role of H2S and synthetic enzymes in Holstein cows with CM is unknown. The aim of this study was to identify DEPs associated with sulfide metabolism and further investigate their ...
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang   +8 more
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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF [PDF]

JACC: Basic to Translational Science
Summary: Heart failure with preserved ejection fraction (HFpEF) presents significant treatment challenges. We assessed hydrogen sulfide (H2S) bioavailability in HFpEF patients and 2 animal models: the ''2-hit'' L-NAME + high-fat diet mouse model and ZSF1
Jake E. Doiron, PhD, Mahmoud H. Elbatreek, PhD, Huijing Xia, PhD, Xiaoman Yu, MS, Natalie D. Gehred, BA, Tatiana Gromova, BS, Jingshu Chen, PhD, Ian H. Driver, PhD, Naoto Muraoka, PhD, Martin Jensen, PhD, Smitha Shambhu, MS, W.H. Wilson Tang, MD, Kyle B. LaPenna, PhD, Thomas E. Sharp, III, PhD, Traci T. Goodchild, PhD, Ming Xian, PhD, Shi Xu, PhD, Heather Quiriarte, MS, Timothy D. Allerton, PhD, Alexia Zagouras, MD, MS, Jennifer Wilcox, BS, Sanjiv J. Shah, MD, Josef Pfeilschifter, PhD, Karl-Friedrich Beck, PhD, Thomas M. Vondriska, PhD, Zhen Li, PhD, David J. Lefer, PhD   +26 more
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Hepatocyte FoxO1 depletion exacerbates hepatic inflammation in MASH by targeting cystathionine γ-lyase [PDF]

Scientific Reports
The transcription factor Forkhead box protein O1 (FoxO1) is a well-established regulator of glucose and lipid metabolism, yet its role in metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis remains debated.
Hui-Ting Chen, Chen Huang, Jia-Wei Chen, Si-Qi Yang, Jie-Min Cheng, Yong-Qiang Li, Han-Qing Chen, Yong-Jian Zhou   +7 more
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