Results 1 to 10 of about 8,420 (116)

6-Bromoindole- and 6-Bromoindazole-Based Inhibitors of Bacterial Cystathionine γ-Lyase Containing 3-Aminothiophene-2-Carboxylate Moiety [PDF]

Molecules
In recent years, a number of synthetic potentiators of antibiotics have been discovered. Their action can significantly enhance the antibacterial effect and limit the spread of antibiotic resistance through inhibition of bacterial cystathionine-γ-lyase ...
Roman A. Novikov, Dmitry N. Platonov, Alexander Yu. Belyy, Konstantin V. Potapov, Maxim A. Novikov, Yury V. Tomilov, Olga I. Kechko, Tatiana A. Seregina, Anastasia S. Zemskaya, Pavel N. Solyev, Vladimir A. Mitkevich   +10 more
doaj   +3 more sources

Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation [PDF]

Scientific Reports, 2023
D,L-Propargylglycine (PAG) has been widely used as a selective inhibitor to investigate the biological functions of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive sulfur species (RSS).
Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, Yasuo Watanabe, Takao Otsuka, Hiroaki Saito, Satoru Nagatoishi, Kouhei Tsumoto, Hirotatsu Kojima, Takayoshi Okabe, Toshiyuki Shimizu, Yasuteru Urano   +18 more
doaj   +3 more sources

Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction [PDF]

Redox Biology, 2022
Hydrogen sulfide (H2S), produced by cystathionine γ lyase (CSE), is an important endogenous gasotransmitter to maintain heart function. However, the molecular mechanism for how H2S influences the mitochondrial morphology during heart failure remains ...
Dan Wu, Bo Tan, Yuanyuan Sun, Qingxun Hu
doaj   +3 more sources

Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa [PDF]

Scientific Reports
The escalating drug resistance among microorganisms underscores the urgent need for innovative therapeutic strategies and a comprehensive understanding of bacteria's defense mechanisms against oxidative stress and antibiotics.
Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz   +11 more
doaj   +3 more sources

Synthesis of the Indole-Based Inhibitors of Bacterial Cystathionine γ-Lyase NL1-NL3 [PDF]

Molecules, 2023
Bacterial cystathionine γ-lyase (bCSE) is the main producer of H2S in pathogenic bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, etc.
Konstantin V. Potapov, Roman A. Novikov, Maxim A. Novikov, Pavel N. Solyev, Yury V. Tomilov, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich   +7 more
doaj   +3 more sources

Sulfur Amino Acid Metabolism and the Role of Endogenous Cystathionine-γ-lyase/H₂S in Holstein Cows with Clinical Mastitis [PDF]

Animals, 2022
H2S plays an important role in various inflammatory diseases. However, the role of H2S and synthetic enzymes in Holstein cows with CM is unknown. The aim of this study was to identify DEPs associated with sulfide metabolism and further investigate their ...
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang   +8 more
doaj   +3 more sources

Cystathionine γ-Lyase Self-Inactivates by Polysulfidation during Cystine Metabolism. [PDF]

Int J Mol Sci, 2023
Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine in the final step of the transsulfuration pathway. It also has β-lyase activity toward cystine, generating cysteine persulfide (Cys-SSH).
Araki S, Takata T, Ono K, Sawa T, Kasamatsu S, Ihara H, Kumagai Y, Akaike T, Watanabe Y, Tsuchiya Y.   +9 more
europepmc   +2 more sources

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner

Nature Communications, 2021
Dietary restriction (DR) can increase protein persulfidation but the tissue specificity of this process is not well understood. Here, the authors compare organ-specific protein persulfidomes in young and aged mice under DR, and show that DR-dependent ...
Nazmin Bithi, Christopher Link, Yoko O. Henderson, Suzie Kim, Jie Yang, Ling Li, Rui Wang, Belinda Willard, Christopher Hine   +8 more
doaj   +2 more sources

Cystathionine γ-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure. [PDF]

Redox Rep, 2023
Objective: Hydrogen sulfide (H2S), the third gasotransmitter, plays a critical role in protecting against heart failure. Sirtuin-1 (SIRT1) is a highly conserved histone deacetylase that has a protective role in the treatment of heart failure by ...
Wu D, Sun Y, Gu Y, Zhu D.
europepmc   +2 more sources

Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor. [PDF]

Hepatology, 2022
Hydrogen sulfide (H2S) plays a protective role in NAFLD. However, whether cystathionine γ lyase (CSE), a dominant H2S generating enzyme in hepatocytes, has a role in the pathogenesis of NAFLD is currently unclear.
Xu W, Cui C, Cui C, Chen Z, Zhang H, Cui Q, Xu G, Fan J, Han Y, Tang L, Targher G, Byrne CD, Zheng MH, Yang L, Cai J, Geng B.   +15 more
europepmc   +2 more sources