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Is cystathionine gamma-lyase protein expressed in the heart?
Biochemical and Biophysical Research Communications, 2012Hydrogen sulfide (H(2)S) has emerged as an important gasotransmitter, offering protection against ischemia-reperfusion damage to the heart. Cystathionine gamma-lyase (CSE) is believed to be the major H(2)S-generating enzyme in the heart. Quite contrary to the general contemplation, CSE protein in cardiac tissues has not been convincingly detected and ...
Ming, Fu +3 more
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Cystathionine γ-lyase from Streptomyces phaeochromoǵenes
1987Publisher Summary This chapter discusses the determination of cystathionine γ- Lyase from streptomyces phaeochromogenes. Cystathionine γ-lyase was first purified and crystallized from rat liver, but is also widely distributed among fungi. The microbial enzyme is purified and crystallized from Streptomyces phaeochromogenes (IFO 3105).
T, Nagasawa, H, Kanzaki, H, Yamada
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Abstract 21141: Cystathionine Gamma-Lyase Regulates Autophagy in Ischemic Endothelial Cells
Circulation, 2017Introduction: Peripheral arterial disease (PAD) is a chronic arterial occlusive disease leading to lower limb ischemia. Autophagy is a cell adaptive response associated with ischemic stress that may act as a double edged sword. It is essential during tissue ischemia, but may also phagocytize more organelles promoting cell death.
Saranya Rajendran, Christopher G Kevil
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Cystathionine gamma lyase (CSE) deficiency promotes increased contraction of the corpus cavernosum
Physiology, 2023Cystathionine γ lyase (CSE) is the primary enzyme responsible for hydrogen sulfide (H2S) production in the vasculature. Although, it is known that H2S is a vasodilator systemically, little is known about the effect of CSE on the arteries and tissues responsible for erectile function. Adequate relaxation of the pre-penile arteries and corpus cavernosum
Tooyib Azeez +2 more
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Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice
Nitric OxideCystathionine gamma-lyase (CSE) is a key enzyme in reverse transsulfuration pathway and contributes to the majority of H2S generation in liver tissues via cysteine metabolism. Dysfunction of the CSE/H2S system is linked to both chronic and acute liver damage.
Samantha Ligi, Arm Ali, Guangdong Yang
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Physiology & Behavior, 2018
Hydrogen sulfide (H2S) is an endogenous neuromodulator produced mainly by the enzyme cystathionine gamma-lyase (CSE) in peripheral tissues. A pronociceptive role of endogenously produced H2S has been previously reported by our group in a model of orofacial inflammatory pain.
Bruna M, Santos +4 more
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Hydrogen sulfide (H2S) is an endogenous neuromodulator produced mainly by the enzyme cystathionine gamma-lyase (CSE) in peripheral tissues. A pronociceptive role of endogenously produced H2S has been previously reported by our group in a model of orofacial inflammatory pain.
Bruna M, Santos +4 more
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Cellular and Molecular Life Sciences, 2010
Hydrogen sulfide (H(2)S) plays an important role in inflammation. We showed that macrophages expressed the H(2)S-forming enzyme cystathionine gamma-lyase (CSE) and produced H(2)S. Lipopolysaccharide (LPS) stimulated the CSE expression and H(2)S production rate. l-cysteine reduced LPS-induced nitric oxide (NO) production.
Xiao-Yan, Zhu +4 more
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Hydrogen sulfide (H(2)S) plays an important role in inflammation. We showed that macrophages expressed the H(2)S-forming enzyme cystathionine gamma-lyase (CSE) and produced H(2)S. Lipopolysaccharide (LPS) stimulated the CSE expression and H(2)S production rate. l-cysteine reduced LPS-induced nitric oxide (NO) production.
Xiao-Yan, Zhu +4 more
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P35 Exacerbation of the septic response in cystathionine-gamma-lyase deficient mice
Nitric Oxide, 2014Previous studies reported both beneficial and detrimental roles of hydrogen sulfide (H2S) in various models of critical illness. The goal of our study was to compare the outcome of septic shock in wild-type mice and in mice deficient in cystathionine-gamma-lyase (CSE).
Ciro Coletta, Csaba Szabo
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Cystathionine gamma lyase expression/activity delays endothelial senescence
Free Radical Biology and Medicine, 2022Sofia Bibli +7 more
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Biochemical and Biophysical Research Communications, 2018
Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement.
Shenzheng, Mo, Yongmei, Hua
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Hydrogen sulfide (H2S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement.
Shenzheng, Mo, Yongmei, Hua
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