Results 1 to 10 of about 814 (60)

Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation [PDF]

Redox Biology, 2023
Purpose: Glioblastoma (GBM) is the most common type of adult brain tumor with extremely poor survival. Cystathionine-gamma lyase (CTH) is one of the main Hydrogen Sulfide (H2S) producing enzymes and its expression contributes to tumorigenesis and ...
Maria Peleli, Ivi Antoniadou, Dorival Mendes Rodrigues-Junior, Odysseia Savvoulidou, Laia Caja, Antonia Katsouda, Daniel F.J. Ketelhuth, Jane Stubbe, Kirsten Madsen, Aristidis Moustakas, Andreas Papapetropoulos   +10 more
doaj   +7 more sources

Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair [PDF]

Cell Communication and Signaling, 2023
Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao, Ting Yang, Meng-Yao Zheng, Peinan Zhao, Li-Ya An, Yu-Xing Qi, Ke-Qian Yi, Peng-Cheng Zhang, Da-Li Sun   +8 more
doaj   +4 more sources

Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study [PDF]

Transplantation Direct
Background. Hydrogen sulfide (H2S) produced endogenously by the CTH gene-encoded cystathionine gamma-lyase protects from renal ischemia–reperfusion injury in preclinical models.
Matthieu Halfon, MD, Raffaella Emsley, Thomas Agius, PhD, Arnaud Lyon, Sébastien Déglise, MD, Manuel Pascual, MD, Korkut Uygun, PhD, Heidi Yeh, MD, Leonardo V. Riella, MD, PhD, James F. Markmann, MD, PhD, Pierre-Yves Bochud, MD, Dela Golshayan, MD, PhD, Alban Longchamp, MD, PhD, the Swiss Transplant Cohort Study   +13 more
doaj   +2 more sources

SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De‐SUMOylation of CTH [PDF]

Advanced Science
Abdominal aortic aneurysm (AAA) is a high‐risk inflammatory disorder. SENP3, a SUMO2/3‐specific protease, is closely involved in the development of cancer. In this study, the aim is to explore the role of SENP3 in macrophages in AAA. It is found that the
Long Chen, Zhaohua Cai, Danrui Xiao, Yiping Shi, Qingqing Xiao, Min Liang, Yangjing Jiang, Yijie Huang, Feng Liang, Guo Zhou, Fei Zhuang, Xia Wang, Huanhuan Huo, Liang Fang, Qin Shao, Ben He   +15 more
doaj   +2 more sources

Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding [PDF]

Scientific Reports
Gastric cancer (GC), known for its high incidence and poor prognosis, urgently necessitates the identification of reliable prognostic biomarkers to enhance patient outcomes.
Haishun Qu, Yunxiao Liang, Quan Guo, Ling Lu, Yanwei Yang, Weicheng Xu, Yitian Zhang, Yijue Qin   +7 more
doaj   +2 more sources

Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis [PDF]

Scientific Reports
Sodium aescinate (SA), a natural plant extract with various bioactivities, is widely used to treat oedema and inflammation in clinics. However, adverse events, including liver injury, kidney injury, and phlebitis, have been reported in patients with SA ...
Chen Xi, Jie Zhou, Xin Zheng, Xiaoyi Fu, Minjuan Xie   +4 more
doaj   +2 more sources

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

Frontiers in Pharmacology, 2023
Hydrogen sulfide (H2S), a gasotransmitter with protective effects in the cardiovascular system, is endogenously generated by three main enzymatic pathways: cystathionine gamma lyase (CTH), cystathionine beta synthase (CBS) and 3-mercaptopyruvate ...
Antonia Katsouda, Antonia Katsouda, Maria Markou, Maria Markou, Paraskevas Zampas, Paraskevas Zampas, Aimilia Varela, Constantinos H. Davos, Valentina Vellecco, Giuseppe Cirino, Mariarosaria Bucci, Andreas Papapetropoulos, Andreas Papapetropoulos   +12 more
doaj   +1 more source

Bioinformatic analyzes and validation of cystathionine gamma-lyase as a prognostic biomarker and related to immune infiltrates in hepatocellular carcinoma

Heliyon, 2023
Background: The role of cystathionine γ-lyase (CTH) in the prognosis and immune invasion of hepatocellular carcinoma (HCC) remains poorly understood. Methods: In this study, the clinical data of patients with HCC were analyzed, and the expression level ...
Jianfeng Xiang, Xinrui Wu, Wangrui Liu, Huagen Wei, Zhu Zhu, Shifan Liu, Chengqi Song, Qiang Gu, Shiyin Wei, Yichi Zhang   +9 more
doaj   +1 more source

Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways

Journal of Fungi, 2022
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao, Chuanzheng Wei, Hui Lin, Peng Zhang, Yuanyuan Liu, Youjin Deng, Qianhui Huang, Baogui Xie   +7 more
doaj   +1 more source

Hypertension and Aging Affect Liver Sulfur Metabolism in Rats

Cells, 2021
Hypertension and age are key risk factors for cardiovascular morbidity and mortality. Hydrogen sulfide (H2S), a gaseous transmitter, contributes significantly to regulating arterial blood pressure and aging processes.
Dominika Szlęzak, Patrycja Bronowicka-Adamska, Tomasz Hutsch, Marcin Ufnal, Maria Wróbel   +4 more
doaj   +1 more source