Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells. [PDF]
Int J Mol Sci, 2023 Manandhar S +4 more
europepmc +3 more sources
Journal of Biological Chemistry, 1984 Cystathionine gamma-lyase (EC 4.4.1.1) is widely distributed in actinomycetes, e.g. genera Streptomyces, Micromonospora, Micropolyspora, Mycobacterium, Nocardia, Streptosporangium, and Streptoverticillium. The enzyme was purified from Streptomyces phaeochromogenes (IFO 3105) in nine steps.
Tôru Nagasawa +2 more
openalex +3 more sources
Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. [PDF]
PLoS ONE, 2014 Hydrogen sulfide (H2S) is an important gaseous signaling molecule that functions in physiological and pathological conditions, such as atherosclerosis. H2S dilates vessels and therefore has been suggested as an anti-atherogenic molecule.
Sau Ha Cheung +3 more
doaj +2 more sources
Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. [PDF]
Exp Eye Res, 2019 Chronic exposure of the retina to light and high concentrations of polyunsaturated fatty acid in photoreceptor cells make this tissue susceptible to oxidative damage. As retinal degenerative diseases are associated with photoreceptor degeneration, the antioxidant activity of both hydrogen sulfide (H2S) and glutathione (GSH) may play an important role ...
Badiei A +4 more
europepmc +4 more sources
Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0160521.].
Ravinder Reddy Gaddam +7 more
doaj +2 more sources
Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms. [PDF]
Antioxid Redox Signal, 2016 To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H2S) in hepatic glucose production under physiological conditions.We found that CSE knockout (KO) mice had a reduced rate of gluconeogenesis, which was reversed by administration of NaHS (an H2S donor) (i.p.).
Untereiner AA, Wang R, Ju Y, Wu L.
europepmc +4 more sources
The Dysregulation of microRNA-30b Directly Regulates Cystathionine Gamma-Lyase and Exhibits Poor Invasion Activity in Preeclampsia. [PDF]
CureusSaxena S, John BA, Verma N, Mishra M.
europepmc +3 more sources
Bioenergetic effects of hydrogen sulfide suppress soluble Flt-1 and soluble endoglin in cystathionine gamma-lyase compromised endothelial cells. [PDF]
Sci Rep, 2020 Sanchez-Aranguren LC +6 more
europepmc +3 more sources
Cellular and Molecular Life Sciences, 2010 Hydrogen sulfide (H(2)S) plays an important role in inflammation. We showed that macrophages expressed the H(2)S-forming enzyme cystathionine gamma-lyase (CSE) and produced H(2)S. Lipopolysaccharide (LPS) stimulated the CSE expression and H(2)S production rate. l-cysteine reduced LPS-induced nitric oxide (NO) production.
Xiaoyan Zhu +4 more
openalex +4 more sources
Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy. [PDF]
Cancer Sci, 2021 Lancien M +13 more
europepmc +3 more sources