Results 21 to 30 of about 41,311 (257)

Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of ‘Papain Superfamily’ Cysteine Proteases

Pharmaceuticals, 2020
Clan C1A or ‘papain superfamily’ cysteine proteases are key players in many important physiological processes and diseases in most living systems. Novel approaches towards the development of their inhibitors can open new avenues in translational medicine.
Manasi Mishra, Vigyasa Singh, Meenakshi B. Tellis, Rakesh S. Joshi, Shailja Singh   +4 more
doaj   +1 more source

Upregulation of Mitochondrial Redox Sensitive Proteins in LPS-Treated Stefin B-Deficient Macrophages

Cells, 2019
Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht−Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism
Mojca Trstenjak Prebanda, Janja Završnik, Boris Turk, Nataša Kopitar Jerala   +3 more
doaj   +1 more source

Comparative transcriptomic analysis-based identification of the regulation of foreign proteins with different stabilities expressed in Pichia pastoris

Frontiers in Microbiology, 2022
IntroductionThe industrial yeast Pichia pastoris is widely used as a cell factory to produce proteins, chemicals and advanced biofuels. We have previously constructed P. pastoris strains that overexpress protein disulfide isomerase (PDI), which is a kind
Tingting Niu, Yi Cui, Xu Shan, Shuzhen Qin, Xuejie Zhou, Rui Wang, Alan Chang, Nan Ma, Jingjing Jing, Jianwei He   +9 more
doaj   +1 more source

Bioinformatics analysis and prokaryotic expression of a cystatin analogue from Spirometra erinaceieuropaei

Biotechnology & Biotechnological Equipment, 2023
Cystatin plays a crucial role in immune evasion by parasites. It regulates diverse immune response processes, such as antigen presentation, cytokine and NO production, and phagocytosis.
Lin Huang, Ling Mai, Gang Lv, Xinjun Chen   +3 more
doaj   +1 more source

Diagnostic and prognostic performance of urinary neutrophil gelatinase‐associated lipocalin in patients with cirrhosis and acute kidney injury

Hepatology, EarlyView., 2022
Diagnostic and prognostic ability of urinary NGAL in patients with cirrhosis and AKI. Abstract Background and Aims Acute kidney injury (AKI) commonly occurs in patients with decompensated cirrhosis. Urinary neutrophil gelatinase–associated lipocalin (uNGAL) could help discriminate between different etiologies of AKI.
Carmine Gambino, Salvatore Piano, Matteo Stenico, Marta Tonon, Alessandra Brocca, Valeria Calvino, Simone Incicco, Nicola Zeni, Roberta Gagliardi, Chiara Cosma, Martina Zaninotto, Patrizia Burra, Umberto Cillo, Daniela Basso, Paolo Angeli   +14 more
wiley   +1 more source

Adding cystatin C to the GRACE scale improves the prediction of bleeding complications in non-invasively treated patients with acute coronary syndrome

Кардиоваскулярная терапия и профилактика, 2012
Aim. To assess the prognostic performance of the GRACE scale extended by cystatin C levels in the prediction of ischemic and hemorrhagic in-hospital complications among patients with acute coronary syndrome (ACS). Material and methods.
M. S. Kharchenko, A. D. Erlikh, E. I. Kosenkov, V. P. Masenko, N. A. Gratsianskyi   +4 more
doaj   +1 more source

Glomerular Filtration Rate Estimation Based on Cystatin C Formulas among Neonates [PDF]

Iranian Journal of Neonatology, 2021
Background: Glomerular filtration rate (GFR) is the best indicator to assess renal function; however, it is difficult to perform it, especially in neonates.
Nasrin Khalesi, Farnoosh Seirafianpour, Rozita Hoseini, Hassan Otukesh, Nahid Rahimzadeh, Shahrbanoo Nakhaie, Golnar Gohardehi, Parisa Mohaghegh   +7 more
doaj   +1 more source

Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer

Pharmaceuticals, 2019
In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and given rise to a number of key areas of interest in the clinical setting.
Surinder M. Soond, Maria V. Kozhevnikova, Paul A. Townsend, Andrey A. Zamyatnin   +3 more
doaj   +1 more source

Egg White Cystatin – A Review

Acta Veterinaria, 2020
Hen eggs are widely used, not only for human consumption, but also as an important material in food production and in pharmaceutical and cosmetics industry.
Patryk Kupaj, Maciej Korus, Malgorzata Korzeniowska, Wieslaw Kopec   +3 more
doaj   +1 more source

Parasite Cystatin: Immunomodulatory Molecule with Therapeutic Activity against Immune Mediated Disorders

Pathogens, 2020
The use of parasites or their products for treating chronic inflammation associated diseases (CIADs) has generated significant attention recently. Findings from basic and clinical research have provided valuable information on strengthening the notion ...
Vishal Khatri, Nikhil Chauhan, Ramaswamy Kalyanasundaram   +2 more
doaj   +1 more source