Results 51 to 60 of about 55,204 (241)

Machine Learning‐Based Radiomics in Malignancy Prediction of Pancreatic Cystic Lesions: Evidence from Cyst Fluid Multi‐Omics

Advanced Science, EarlyView.
This study develops noninvasive clinical‐radiomic models using preoperative CT images to predict the malignant potential of pancreatic cystic lesions. It demonstrates the models' high accuracy across various datasets, with AUCs exceeding 0.92. Additionally, multi‐omics analyses uncover key biological mechanisms, including secretion function and lipid ...
Sihang Cheng, Ge Hu, Shenbo Zhang, Rui Lv, Limeng Sun, Zhe Zhang, Zhengyu Jin, Yanyan Wu, Chen Huang, Lu Ye, Yunlu Feng, Zhe‐Sheng Chen, Zhiwei Wang, Huadan Xue, Aiming Yang   +14 more
wiley   +1 more source

Cystatin and glomerular filtration rate equations in old renal transplant donors

The Egyptian Journal of Internal Medicine, 2019
Introduction Early detection of renal dysfunction in live kidney donors is important and needs easy reliable tools. The aim of the study is to evaluate the cystatin level and cystatin-based equation in assessment of renal function in old healthy kidney ...
Ahmed Y Ali, Sahier O Elkhashab
doaj   +1 more source

Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) [PDF]

, 2013
Background: The Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) is a large, prospective, pan-Canadian, cohort study designed to improve our understanding of determinants of renal and cardiovascular (CV ...
Brendan, Barrett, Clase, Catherine M, Djurdjev, Ognjenka, Holmes, Daniel, Levin, Adeera, Madore, Francois, Muirhead, Norman, on behalf of the CanPREDDICT investigators, Rigatto, Claudio, Tang, Mila   +9 more
core   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Correlation between serum homocysteine level and clinicopathological factors of IgA nephropathy

Linchuang shenzangbing zazhi
ObjectiveTo investigate the correlation between serum homocysteine （Hcy） and clinicopathologic factors of immunoglobulin A nephropathy （IgAN）.MethodsA total of 349 patients with IgAN diagnosed by renal biopsy in the Nephrology Department of Longhua ...
Cai Xiao-fan, Huang Jie-bo, Xing Yue, Cai Xiu-feng, Li Xue-ling, Zhong Yi-fei   +5 more
doaj   +1 more source

The Carboxypeptidase Activity of Cathepsin X is Not Controlled by Endogenous Inhibitors

Acta Chimica Slovenica, 2019
Cysteine cathepsins are peptidases with housekeeping functions that play different specific roles in different tissues. Endogenous peptidase inhibitors, such as cystatins and thyropins are the ultimate way of controlling their activity.
Urša Pečar Fonović, Milica Perišić Nanut, Nace Zidar, Brigita Lenarčič, Janko Kos   +4 more
doaj   +1 more source

Risk Factors and Predictive Models for Sarcopenia in Older Adults

AGING MEDICINE, EarlyView.
Independent risk factors for sarcopenia identified by Lasso regression and logistic regression in the study were BMI, prealbumin, albumin/globulin ratio (A/G ratio), serum creatinine, and phosphorus. These factors were used to construct a nomogram model and a decision tree model. Both models showed effectiveness in predicting sarcopenia in older adults,
Shiyuan Zhang, Xue Yang, Nina An, Meng Lv, Lanyu Yang, Rui Liu, Song Hu, Weiguo Chen, Wenjing Feng, Yongjun Mao   +9 more
wiley   +1 more source

Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery; a randomised controlled pilot study (ISRCTN 11799696) Fluid optimisation for emergency surgery [PDF]

, 2008
<b>Background:</b> Emergency abdominal surgery carries a high risk of postoperative morbidity and mortality. Goal directed therapy has been advocated to improve outcome in high-risk surgery.
A. Hay, B. McCreath, Bennett-Guerrero, Biondo, Biondo, Bone, Boyd, Brandstrup, C.S. McArdle, Cook, D.C. McMillan, Gan, Harten, Harten, Holte, J. Harten, J. Kinsella, J.E.M. Crozier, Kern, Lee, Lobo, MacKay, Michard, Nisanevich, Noblett, Pearse, Prytherch, Shoemaker, Story, Vincent, Wakeling, Wilkes, Wilson   +32 more
core   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source