Results 101 to 110 of about 60,453 (247)

Acute kidney injury in critically ill cancer patients : an update [PDF]

, 2016
Patients with cancer represent a growing group among actual ICU admissions (up to 20 %). Due to their increased susceptibility to infectious and noninfectious complications related to the underlying cancer itself or its treatment, these patients ...
Benoit, Dominique, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond   +3 more
core   +2 more sources

Molecular analysis of 3D domain swapping in the acylphosphatase from Escherichia coli

Acta Crystallographica Section D, EarlyView.
Structures of the monomer and intertwined dimer of the acylphosphatase from E. coli shed light on the molecular basis of its 3D domain swapping.Three‐dimensional domain swapping is a mechanism by which proteins form oligomers. At present, the molecular basis that dictates whether some proteins fold in their monomeric form or as intertwined oligomers is
Sergio Martínez-Rodríguez, Jose A. Gavira, M. Carmen Salinas-Garcia, Montserrat Andujar-Sánchez, Ana Camara-Artigas   +4 more
wiley   +1 more source

Cystatin C proteoforms in chronic kidney disease

PLoS ONE, 2023
Cystatin C, a cysteine protease inhibitor, is used as a biomarker of renal function. It offers several advantages compared to creatinine, and formulas for the estimation of the glomerular filtration rate based on cystatin C have been developed. Recently,
Helene Dahl, Klaus Meyer, Kristina Sandnes, Natasha Lervaag Welland, Iselin Arnesen, Hans-Peter Marti, Jutta Dierkes, Vegard Lysne   +7 more
doaj  

Exploration of chronic kidney disease prevalence estimates using new measures of kidney function in the health survey for England

, 2015
Background: chronic kidney disease (CKD) diagnosis relies on glomerular filtration rate (eGFR) estimation, traditionally using the creatinine-based Modification of Diet in Renal Disease (MDRD) equation.
Aitken, Grant, Day, Julie, Fraser, Simon D.S., Mindell, Jennifer S., Moon, Graham, O’Donoghue, Donal, Roderick, Paul J., Taal, Maarten W.   +7 more
core   +1 more source

Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora. [PDF]

, 2015
BACKGROUND: Downy mildews are the most speciose group of oomycetes and affect crops of great economic importance. So far, there is only a single deeply-sequenced downy mildew genome available, from Hyaloperonospora arabidopsidis.
Bode, Helge B, Cano, Liliana M, Dep Biologie, Evangelisti, Edouard, Govers, Francine, Judelson, Howard, Kamoun, Sophien, Kemen, Eric, Kitner, Miloslav, Klein, Joël, Meijer, Harold J G, Oome, Stan, Plant Microbe Interactions, Sambles, Christine, Schornack, Sebastian, Sharma, Rahul, Spring, Otmar, Studholme, David J, Sub Plant-Microbe Interactions, Thines, Marco, Van den Ackerveken, Guido, van den Hoogen, D Johan, Win, Joe, Xia, Xiaojuan, Zipper, Reinhard   +24 more
core   +5 more sources

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on

Acta Ophthalmologica, EarlyView.
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg   +4 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients

Mediators of Inflammation, 2020
This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19.
Dan Chen, Wenwu Sun, Jia Li, Bohua Wei, Wei Liu, Xiaopin Wang, Fan Song, Liangkai Chen, Junhui Yang, Li Yu   +9 more
doaj   +1 more source

Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate

Cardiovascular Diabetology, 2012
Background All of the components of Metabolic syndrome (MetS) have been regarded as risk factors for coronary artery disease (CAD). Early detection of CAD in asymptomatic patients with MetS remains a challenge.
Qing Xie, Furong Wang, Yunxia Liu, Jian Zhang, Xuping Wang, Ling Gao   +5 more
doaj   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source