Results 111 to 120 of about 60,453 (247)
Renal Failure, 2019 Background: Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear.
Xiao-Ran Zhu +4 more
doaj +1 more source
Cystatin C Predicts Incident Cardiovascular Disease in Twins
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCystatin C is associated with both renal function and atherosclerotic cardiovascular disease (ASCVD). We have previously shown a genetic correlation between cystatin C and prevalent ASCVD.
Johannes Arpegård +6 more
doaj +1 more source
Cell Proliferation, EarlyView.Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei +7 more
wiley +1 more source
Clinical Association of Cystatin C and Atrial Fibrillation in Chinese Elderly
International Journal of Gerontology, 2015 Background: Atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only an inflammatory marker but also an independent predictor of cardiovascular events.
Ping Liu, Yunqi Jiang, Juan Meng
doaj +1 more source
Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Renal microvascular dysfunction is a central driver of diabetic kidney disease, yet the potential for rapid therapeutic reversal remains obscure. We investigated the effect of short‐term liraglutide on early changes in the renal microcirculation post‐induction of diabetes.
Yuan Li +8 more
wiley +1 more source
The regulatory role of cystatin C in autophagy and neurodegeneration
Вавиловский журнал генетики и селекции, 2019 Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is particularly important in neurons, which do not have a proliferative option for cellular repair ...
T. A. Korolenko +9 more
doaj +1 more source
Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]
, 2018 IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael +10 more
core
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Journal of Diabetes InvestigationObjective To explore the causal relationship between cystatin C levels and different stages of diabetic retinopathy through Mendelian randomization (MR).
Yimeng Ruan +4 more
doaj +1 more source