Results 31 to 40 of about 25,803 (305)

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum

EBioMedicine, 2015
Background: Cysteamine has recently been shown to have in vitro properties potentially therapeutically beneficial in cystic fibrosis (CF). In this study we investigated the antimicrobial and mucolytic activity of cysteamine against the complex biologic ...
Graham Devereux, Douglas Fraser-Pitt, Jennifer Robertson, Edward Devlin, Derry Mercer, Deborah O'Neil   +5 more
doaj   +1 more source

Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: the role of bases in promoting the formation of fluorescent S-acyl derivatives through S–N Smiles rearrangement [PDF]

, 2012
The acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan has been investigated. Depending on the use of the base, a competitive Smiles rearrangement occurs during the acylation step leading to the formation of N-acyl and/or fluorescent S-acyl ...
Ah-Kow, Al-Kaysi, Allen, Bem, Borisenko, Buncel, Burchfield, Castagnolo, Daniele Castagnolo, Ferguson, Fu, Ghosh, Ioannis, Lavis, Mafalda Pagano, Martina Bernardini, Maurizio Botta, Numasawa, Radi, Radi, Shipton, Terrier, Uchiyama, Uchiyama, Uchiyama, Uchiyama, Warren, Wieland   +27 more
core   +1 more source

Ophthalmic Outcome in a Belgian Cohort of Cystinosis Patients Treated with a Compounded Preparation of Cysteamine Eye Drops: Retrospective Analysis

Ophthalmology and Therapy, 2019
Introduction Treatment of the anterior segment problems in cystinosis is challenging as oral cysteamine is ineffective in the treatment of corneal problems because of its avascular structure.
Freya Peeters, Catherine Cassiman, Karel Van Keer, Elena Levtchenko, Koenraad Veys, Ingele Casteels   +5 more
doaj   +1 more source

Impact of Dietary Supplementation of Cysteamine on Egg Taurine Deposition, Egg Quality, Production Performance and Ovary Development in Laying Hens

Animals, 2023
This study aimed to examine the effect of dietary cysteamine on yolk taurine content in hens during different egg production periods. In Exp. 1, China Agricultural University-3 (CAU-3) hens at the peak stage of egg production (aged 31 wks) were used to ...
Jing Chen, Youli Wang, Zhenhai Tang, Xiaorui Guo, Jianmin Yuan   +4 more
doaj   +1 more source

Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis.

Journal of the American Society of Nephrology, 2020
BACKGROUND Mutations in CTNS-a gene encoding the cystine transporter cystinosin-cause the rare, autosomal, recessive, lysosomal-storage disease cystinosis.
J. Hollywood, Aneta Przepiorski, R. D’Souza, Sreevalsan Sreebhavan, E. Wolvetang, P. Harrison, A. Davidson, Teresa M. Holm   +7 more
semanticscholar   +1 more source

Synthesis of a new amino acid derivative with long-lasting hair shape control effects and elucidation of its mechanisms. [PDF]

Int J Cosmet Sci
We have discovered 2‐(2‐aminoethylthio) succinic acid with a long‐lasting hair shape control effect. We have demonstrated its hair straightening and curl retention effect, and clarified its mechanism. Abstract Objective Hair is a crucial aspect of an individual's physical appearance.
Sato S, Tabuchi H, Katayama K, Matsumoto K, Miyamoto H, Kanno S, Sekiguchi H, Tanaka Y, Inoue M, Murata C, Hotta H, Tsujino Y.   +11 more
europepmc   +2 more sources

The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes [PDF]

, 2015
As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-
Medvedeva, N. P., Rusinov, V. L., Sapozhnikova, I. S., Ulomskii, E. N.   +3 more
core   +3 more sources

Remotely triggered scaffolds for controlled release of pharmaceuticals [PDF]

, 2013
Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery.
Hoskins, Clare, Lees, Martin R., McGarvey, David J., Roach, Paul, Ph.D.   +3 more
core   +2 more sources

The specificity of cysteamine oxygenase

FEBS Letters, 1975
Oxidation of cysteamine to hypotaurine is catalyzed by cysteamine oxygenase (EC 1.13.11.19), a non-heme iron enzyme of large distribution [l-3] . A similar oxidation of cysteine to cysteine sulfinic acid has been reported to require a different oxygenase [4,.5]. Specificity of cysteamine oxygenase has been studied earlier in this laboratory by assaying
Federici G, Silvestro Duprè, Doriano Cavallini, C. De Marco, A. Antonucci, Giorgio Ricci   +5 more
openaire   +3 more sources

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

PLoS ONE, 2020
BackgroundEmerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge.
Graham Devereux, Danielle Wrolstad, Stephen J Bourke, Cori L Daines, Simon Doe, Ryan Dougherty, Rose Franco, Alastair Innes, Benjamin T Kopp, Jorge Lascano, Daniel Layish, Gordon MacGregor, Lorna Murray, Daniel Peckham, Vincenzina Lucidi, Emma Lovie, Jennifer Robertson, Douglas J Fraser-Pitt, Deborah A O'Neil   +18 more
doaj   +1 more source