Effect of cysteamine and 13-cis-retinoic acid on bovine in vitro embryo production [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 One of the main factors decreasing the success of an in vitro embryo production is oxidative stress-mediated reactive oxygen species resulting in cellular damages.
Abdolreza RANJBAR +2 more
doaj +1 more source
Remotely triggered scaffolds for controlled release of pharmaceuticals [PDF]
, 2013 Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery.
Hoskins, Clare +3 more
core +2 more sources
X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Copper-cysteamine nanoparticles can be activated directly by X-rays to produce singlet oxygen. The use of copper-cysteamine nanoparticles (conjugated with pH-low insertion peptide) can enhance the effects of X-ray–induced photodynamic ...
Samana Shrestha +9 more
semanticscholar +1 more source
Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine [PDF]
, 2015 To overcome the major disadvantages of cysteamine, the only registered treatment for the rare genetic disease cystinosis, nine prodrugs of γ-glutamyl-cysteamine (4) were synthesized for evaluation.
Anderson, Rosaleen +5 more
core +1 more source
Hayati Journal of Biosciences, 2020 Low nuclear maturation and fertilization rate is one obstacle in the in vitro embryo production which decrease embryo yield. This problem is presumable related with high production of reactive oxygen species (ROS) during maturation process.
Feni Dwi Kartika Gulo +2 more
doaj +1 more source
Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis [PDF]
Farmacia Hospitalaria, 2017 Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients’ eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal ...
Anxo Fernández-Ferreiro +9 more
doaj +1 more source
The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes [PDF]
, 2015 As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-
Medvedeva, N. P. +3 more
core +3 more sources
Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages. [PDF]
PLoS ONE, 2017 Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to
Chandra L Shrestha +8 more
doaj +1 more source
Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]
, 2017 The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu +6 more
core +1 more source
Journal of Chemistry, 2013 A carbon-paste electrode modified with ferrocenecarboxaldehyde and NiO nanoparticle (NiO/NPs) was used for the sensitive and selective voltammetric determination of cysteamine in the presence of tryptophan.
Hassan Karimi-Maleh +4 more
doaj +1 more source