Results 1 to 10 of about 893,707 (315)

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress [PDF]

Nature Communications, 2018
Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated events.
Gottlieb, Eyal, Lilla, Sergio, van der Reest, Jiska, Zanivan, Sara, Zheng, Liang   +4 more
core   +3 more sources

The cysteine proteome.

Free Radical Biology and Medicine, 2015
The cysteine (Cys) proteome is a major component of the adaptive interface between the genome and the exposome. The thiol moiety of Cys undergoes a range of biologic modifications enabling biological switching of structure and reactivity. These biological modifications include sulfenylation and disulfide formation, formation of higher oxidation states,
Y. Go, J. D. Chandler, Dean P. Jones
semanticscholar   +4 more sources

Extracellular cysteine in connexins: Role as redox sensors [PDF]

Frontiers in Physiology, 2016
Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D., Del Rio, R., García, I.E., González, C., Pinto, B.I., Pupo, A., Retamal, M.A., Stehberg, J.   +7 more
core   +2 more sources

Up-Converting Nanocrystals Modified With Fluorescent Markers for the Detection of Amino Acids: Preparation, Characterization, and Sensing Performance

Frontiers in Chemistry, 2022
The present work was devoted to developing rhodamine-like chemosensing systems for cysteine (Cys) optical recognition. Aiming at low background light and minimal photobleaching effect, up-converting nanocrystals were firstly synthesized and latterly ...
YuLang Fei, Kun Wu, Liang Liu, Liang Liu
doaj   +1 more source

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]

Open Biology, 2020
Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova   +1 more
doaj   +1 more source

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Science, 2020
Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment.
Michael A. Badgley, Daniel M. Kremer, H. C. Maurer, Kathleen E. DelGiorno, Ho-Joon Lee, V. Purohit, Irina R. Sagalovskiy, Alice Ma, Jonathan Kapilian, Christina E. M. Firl, Amanda R. Decker, Stephen A. Sastra, Carmine F. Palermo, Leonardo R. Andrade, Peter Sajjakulnukit, Li Zhang, Zachary P. Tolstyka, Tal Hirschhorn, Candice Lamb, Tong Liu, W. Gu, E. S. Seeley, E. Stone, G. Georgiou, U. Manor, A. Iuga, G. Wahl, B. Stockwell, C. Lyssiotis, K. Olive   +29 more
semanticscholar   +1 more source

Case report: Biochemical and clinical phenotypes caused by cysteine substitutions in the epidermal growth factor-like domains of fibrillin-1

Frontiers in Genetics, 2022
Marfan syndrome, an autosomal dominant disorder of connective tissue, is primarily caused by mutations in the fibrillin-1 (FBN1) gene, which encodes the protein fibrillin-1.
Xin Liu, Kaiqing Liu, Danyao Nie, Jing Zhang, Liyun Zhang, Xinhua Liu, Jiantao Wang   +6 more
doaj   +1 more source

Preoperative Short‐Term Restriction of Sulfur‐Containing Amino Acid Intake for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Double‐Blind, Translational Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Acute kidney injury (AKI) is a major risk factor for chronic kidney disease and increased mortality. Until now, no compelling preventive or therapeutic strategies have been identified. Dietary interventions have been proven highly effective in
Thomas Osterholt, Claas Gloistein, Polina Todorova, Ingrid Becker, Katja Arenskrieger, Ramona Melka, Felix C. Koehler, Michael Faust, Thorsten Wahlers, Thomas Benzing, Roman‐Ulrich Müller, Franziska Grundmann, Volker Burst   +12 more
doaj   +1 more source

Non-canonical glutamate-cysteine ligase activity protects against ferroptosis

bioRxiv, 2020
Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation ...
Y. Kang, Andrea Mockabee-Macias, Chang-An Jiang, I. Harris, G. DeNicola   +4 more
semanticscholar   +1 more source

Cysteine and homocysteine as biomarker of various diseases

Food Science & Nutrition, 2020
Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine.
Tahniat Rehman, M. Shabbir, M. Inam-ur-Raheem, Muhammad Faisal Manzoor, N. Ahmad, Zhi-Wei Liu, M. Ahmad, Azhari Siddeeg, Muhammad Abid, Rana Muhammad Aadil   +9 more
semanticscholar   +1 more source