Results 1 to 10 of about 1,094,535 (338)
Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress [PDF]
Nature Communications, 2018 Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated events.
Gottlieb, Eyal +4 more
core +3 more sources
Extracellular cysteine in connexins: Role as redox sensors [PDF]
Frontiers in Physiology, 2016 Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D. +7 more
core +3 more sources
50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis
Redox Biology, 2023 Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress.
James N. Cobley
doaj +1 more source
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Nature Cancer, 2022 Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces
H. Alborzinia +38 more
semanticscholar +1 more source
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease [PDF]
Open Biology, 2020 Redox imbalance and persistent inflammation are the underlying causes of most chronic diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox homeostasis and resolving acute inflammatory responses.
Sharadha Dayalan Naidu +1 more
doaj +1 more source
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation
Biochemistry, 2022 Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important yet complex regulatory roles.
Diego Garrido Ruiz +4 more
semanticscholar +1 more source
Nanomaterials, 2021 The exchange of primary hydrophobic ligands for hydrophilic ones was studied for two types of alloyed AgInS2-ZnS nanocrystals differing in composition and by consequence exhibiting two different emission colors: red (R) and green (G).
Patrycja Kowalik +3 more
doaj +1 more source
Stoichiometric Thiol Redox Proteomics for Quantifying Cellular Responses to Perturbations
Antioxidants, 2021 Post-translational modifications regulate the structure and function of proteins that can result in changes to the activity of different pathways. These include modifications altering the redox state of thiol groups on protein cysteine residues, which ...
Nicholas J. Day +2 more
doaj +1 more source
bioRxiv, 2021 As one of the three mammalian gasotransmitters, hydrogen sulfide (H2S) plays a major role in maintaining physiological homeostasis. Endogenously produced H2S plays numerous beneficial roles including mediating vasodilation and conferring neuroprotection.
Domenick J. Braccia +3 more
semanticscholar +1 more source
How the Competition for Cysteine May Promote Infection of SARS-CoV-2 by Triggering Oxidative Stress
Antioxidants, 2023 SARS-CoV-2 induces a broad range of clinical manifestations. Besides the main receptor, ACE2, other putative receptors and co-receptors have been described and could become genuinely relevant to explain the different tropism manifested by new variants ...
Annamaria Vernone +4 more
doaj +1 more source