Results 1 to 10 of about 1,002,644 (386)

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress [PDF]

Nature Communications, 2018
Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated events.
Jiska van der Reest, S. Lilla, Liang Zheng, S. Zanivan, E. Gottlieb   +4 more
semanticscholar   +4 more sources

Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation [PDF]

Biomolecules
Aging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems.
Marta Pace, Chiara Giorgi, Giorgia Lombardozzi, Annamaria Cimini, Vanessa Castelli, Michele d’Angelo   +5 more
doaj   +2 more sources

Extracellular Cysteine in Connexins: Role as Redox Sensors [PDF]

Frontiers in Physiology, 2016
Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
M. Retamal, Isaac E. García, Bernardo I. Pinto, A. Pupo, David Báez, J. Stehberg, R. Del Río, Carlos Gonzalez   +7 more
semanticscholar   +4 more sources

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads [PDF]

Frontiers in Immunology, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Chandra S. Chirumamilla, Ajay Palagani, Balu Kamaraj, Ken Declerck, Marinus W. C. Verbeek, Ryabtsova Oksana, Karolien De Bosscher, Nadia Bougarne, Bart Ruttens, Kris Gevaert, René Houtman, Winnok H. De Vos, Jurgen Joossens, Pieter Van Der Veken, Koen Augustyns, Xaveer Van Ostade, Annemie Bogaerts, Hans De Winter, Wim Vanden Berghe   +18 more
doaj   +4 more sources

50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis

Redox Biology, 2023
Oxidative stress is biochemically complex. Like primary colours, specific reactive oxygen species (ROS) and antioxidant inputs can be mixed to create unique “shades” of oxidative stress.
James N. Cobley
doaj   +1 more source

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Nature Cancer, 2022
Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces
H. Alborzinia, Andrés F. Flórez, Sina Kreth, L. Brückner, Umut Yildiz, Moritz Gartlgruber, Dorett I Odoni, Gernot Poschet, Karolina Garbowicz, Chunxuan Shao, C. Klein, Jasmin Meier, Petra Zeisberger, Michal Nadler-Holly, Matthias Ziehm, F. Paul, J. Burhenne, E. Bell, Marjan Shaikhkarami, Roberto Würth, Sabine A. Stainczyk, Elisa M Wecht, Jochen Kreth, M. Büttner, Naveed Ishaque, M. Schlesner, B. Nicke, Carlo Stresemann, Maria Llamazares-Prada, J. Reiling, M. Fischer, I. Amit, M. Selbach, C. Herrmann, S. Wölfl, K. Henrich, T. Höfer, A. Trumpp, F. Westermann   +38 more
semanticscholar   +1 more source

Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation

Biochemistry, 2022
Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important yet complex regulatory roles.
Diego Garrido Ruiz, Angélica Sandoval-Pérez, A. Rangarajan, Emma L Gunderson, Matthew P. Jacobson   +4 more
semanticscholar   +1 more source

Redox regulation of enzymes involved in sulfate assimilation and in the synthesis of sulfur-containing amino acids and glutathione in plants

Frontiers in Plant Science, 2022
Sulfur is essential in plants because of its presence in numerous molecules including the two amino acids, cysteine, and methionine. Cysteine serves also for the synthesis of glutathione and provides sulfur to many other molecules including protein ...
Linda de Bont, Natacha Donnay, Jérémy Couturier, Jérémy Couturier, Nicolas Rouhier   +4 more
doaj   +1 more source

Label-Free Quantitative Proteomic Analysis of Nitrogen Starvation in Arabidopsis Root Reveals New Aspects of H₂S Signaling by Protein Persulfidation

Antioxidants, 2021
Hydrogen sulfide (H2S)-mediated signaling pathways regulate many physiological and pathophysiological processes in mammalian and plant systems.
Ana Jurado-Flores, Luis C. Romero, Cecilia Gotor   +2 more
doaj   +1 more source

Reaction of Chalcones with Cellular Thiols. The Effect of the 4-Substitution of Chalcones and Protonation State of the Thiols on the Addition Process. Diastereoselective Thiol Addition

Molecules, 2021
Several biological effects of chalcones have been reported to be associated with their thiol reactivity. In vivo, the reactions can result in the formation of small-molecule or protein thiol adducts.
Fatemeh Kenari, Szilárd Molnár, Pál Perjési   +2 more
doaj   +1 more source