Results 21 to 30 of about 747,792 (297)
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Science, 2020 Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment.
Michael A. Badgley +30 more
semanticscholar +1 more source
Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development
Molecules, 2022 Cysteine is one of the least abundant amino acids in proteins of many organisms, which plays a crucial role in catalysis, signal transduction, and redox regulation of gene expression.
Fangjiao Huang +3 more
semanticscholar +1 more source
Plant, Soil and Environment, 2021 Recently, plant-available sulphur (S) in the soil is decreasing due to the limited use of S containing fertilisers and the reduction of atmospheric S deposition. The aim of this work was to evaluate the S status in a long-term fertilisation experiment on
Evelin Kármen Juhász +3 more
doaj +1 more source
bioRxiv, 2021 As one of the three mammalian gasotransmitters, hydrogen sulfide (H2S) plays a major role in maintaining physiological homeostasis. Endogenously produced H2S plays numerous beneficial roles including mediating vasodilation and conferring neuroprotection.
Domenick J. Braccia +3 more
semanticscholar +1 more source
Non-canonical glutamate-cysteine ligase activity protects against ferroptosis
bioRxiv, 2020 Cysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation ...
Y. Kang +4 more
semanticscholar +1 more source
Cysteine and homocysteine as biomarker of various diseases
Food Science & Nutrition, 2020 Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine.
Tahniat Rehman +9 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Marfan syndrome, an autosomal dominant disorder of connective tissue, is primarily caused by mutations in the fibrillin-1 (FBN1) gene, which encodes the protein fibrillin-1.
Xin Liu +6 more
doaj +1 more source
Frontiers in Immunology, 2022 As the precursor of taurine, cysteine serves physiological functions, such as anti-oxidative stress and immune improvement. Investigation of cysteine and its derivatives has made positive progress in avian and mammalian species, yet the study and ...
Jia-Xing Liu +13 more
doaj +1 more source
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Cell, 2020 Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins; however, our understanding of ...
E. Vinogradova +27 more
semanticscholar +1 more source
Viral cysteine proteinases [PDF]
Perspectives in Drug Discovery and Design, 1996 Dozens of novel cysteine proteinases have been identified in positive single-stranded RNA viruses and, for the first time, in large double-stranded DNA viruses. The majority of these proteins are distantly related to papain or chymotrypsin and may be direct descendants of primordial proteolytic enzymes.
Gorbalenya, Alexander E. +1 more
openaire +2 more sources