Results 11 to 20 of about 654,528 (315)

Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe [PDF]

, 2022
Covalent inhibitors of enzymes are increasingly appreciated as pharmaceutical seeds, yet discovering non-cysteine-targeting inhibitors remains challenging.
Naotaka Noda, Ken Tajiri, Lu Zhou, Naotaka Noda (6558761), Junichiro Takaya (1453048), Shin-ichi Sato, Junichiro Takaya, Masahiro Abo (716769), Motonari Uesugi (509631), Yejin Jung, Changyi Cui, Shin-ichi Sato (1452955), Masahiro Abo, Kohei Toh, Ken Tajiri (11998309), Yejin Jung (11998306), Lu Zhou (230418), Kohei Toh (9748288), Motonari Uesugi, Changyi Cui (287752)   +19 more
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Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

Antioxidants, 2021
The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD).
Chien-Ning Hsu, You-Lin Tain
doaj   +1 more source

Bacterial Cysteine-Inducible Cysteine Resistance Systems [PDF]

Journal of Bacteriology, 2016
ABSTRACT Cysteine donates sulfur to macromolecules and occurs naturally in many proteins. Because low concentrations of cysteine are cytotoxic, its intracellular concentration is stringently controlled. In bacteria, cysteine biosynthesis is regulated by feedback inhibition of the activities of serine acetyltransferase (SAT) and 3-
Kazuhiro, Takumi, Gen, Nonaka
openaire   +2 more sources

Toward Food Freshness Monitoring: Coordination Binding–Based Colorimetric Sensor Array for Sulfur-Containing Amino Acids

Frontiers in Chemistry, 2021
Herein, a self-assembled colorimetric chemosensor array composed of off-the-shelf catechol dyes and a metal ion (i.e., Zn2+) has been used for the sulfur-containing amino acids (SCAAs; i.e., glutathione, glutathione disulfide, L–cysteine, DL–homocysteine,
Xiaojun Lyu, Wei Tang, Yui Sasaki, Jie Zhao, Tingting Zheng, Yang Tian, Tsuyoshi Minami   +6 more
doaj   +1 more source

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Mottram Jeremy C., Richard J Marhöfer, Schröder Jörg, Selzer, P.M., Schroder, J., Noack, Sandra, Noack Sandra, Schröder, Jörg, Noack, S., Mottram, J.C., Sandra Noack, Coombs, G.H., Coombs, Graham H, Marhöfer, Richard J, Coombs Graham H., Paul M Selzer, Jeremy C Mottram, Marhöfer Richard J., Marhofer, R.J., Jörg Schröder, Selzer Paul M., Selzer, Paul M, Selzer, Paul M., Graham H Coombs   +24 more
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Transcriptome Analysis of Maize Immature Embryos Reveals the Roles of Cysteine in Improving Agrobacterium Infection Efficiency

Frontiers in Plant Science, 2017
Maize Agrobacterium-mediated transformation efficiency has been greatly improved in recent years. Antioxidants, such as, cysteine, can significantly improve maize transformation frequency through improving the Agrobacterium infection efficiency. However,
Yan Liu, Yan Liu, Zhiqiang Zhang, Zhiqiang Zhang, Junjie Fu, Guoying Wang, Jianhua Wang, Yunjun Liu   +7 more
doaj   +1 more source

Interactive Effects of Glycine Equivalent, Cysteine, and Choline on Growth Performance, Nitrogen Excretion Characteristics, and Plasma Metabolites of Broiler Chickens Using Neural Networks Optimized with Genetic Algorithms

Animals, 2020
Responses of broiler chickens to dietary glycine equivalent (Glyequi) are affected by dietary cysteine and choline. Hence, this study investigated interactive effects among dietary Glyequi, cysteine, and choline on the growth of broiler chickens.
Philipp Hofmann, Wolfgang Siegert, Hamed Ahmadi, Jochen Krieg, Moritz Novotny, Victor D. Naranjo, Markus Rodehutscord   +6 more
doaj   +1 more source

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 [PDF]

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Tarsis F Gesteira, Gesteira Tarsis F., Sanya J Sanderson, Tersariol, Ivarne L.S., Westrop, Gareth, Sansevero, Thiago M., Shida, Claudio S. [UNIFESP], Manfredi, Marcella A, Tersariol, Ivarne Luis dos Santos [UNIFESP], Gerson P Souza, Ivarne L S Tersariol, Luiz Juliano, Manfredi Marcella A., Gareth D Westrop, Sansevero Thiago M., Almeida Paulo C., Tersariol Ivarne L. S., Souza, Gerson A., Manfredi, Marcella A., Sanderson Sanya J., Thiago M Sansevero, Souza, Gerson P., Juliano, Luiz, Westrop, Gareth D., Almeida, Paulo C. [UNIFESP], Judice, W.A.S., Paulo C Almeida, Judice Wagner A. S., Coombs Graham H., Coombs, Graham H., Shida, Claudio S., Shida Cláudio S., Cláudio S Shida, Souza Gerson P., Almeida, Paulo C, Judice, Wagner A. S., Marcella A Manfredi, Sanderson, Sanya J, Coombs, Graham, Juliano, Luiz [UNIFESP], Wagner A S Judice, Juliano Luiz, Sanderson, Sanya J., Graham H Coombs, Westrop Gareth D.   +45 more
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Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases

Frontiers in Neurology, 2019
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms.
Bindu D. Paul, Solomon H. Snyder, Solomon H. Snyder, Solomon H. Snyder   +3 more
doaj   +1 more source

Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]

, 2003
Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
M\ue9nard, Robert, N\ue4gler, Dorit K., Nägler, D. K., Ménard, R.   +3 more
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