Chemo-selective modification of cysteine residue: synthesis and application in the discovery of potential drug candidates [PDF]
Exploration of Drug ScienceChemo-select modification of peptides, targeting a handful of the most reactive proteinogenic amino acids (AAs), is gradually utilized to address the medical needs of peptide drugs and biopharmaceuticals.
Yanyan Liao, Xuefeng Jiang
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The versatile utility of cysteine as a target for cancer treatment
Frontiers in Oncology, 2023 Owing to its unique nucleophilicity, cysteine is an attractive sulfhydryl-containing proteinogenic amino acid. It is also utilized in various metabolic pathways and redox homeostasis, as it is used for the component of major endogenous antioxidant ...
Jin-Young Min +2 more
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Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water
Science, 2020 Cysteine as peptide precursor and catalyst Among amino acids, cysteine is highly reactive as a nucleophile, metal ligand, and participant in redox and radical reactions. These properties make cysteine attractive as a component of prebiotic chemistry, but
Callum S. Foden +5 more
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A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System
Frontiers in Microbiology, 2017 IgaA is an integral inner membrane protein that was discovered as repressor of the RcsCDB phosphorelay system in the intracellular pathogen Salmonella enterica serovar Typhimurium.
M. Graciela Pucciarelli +4 more
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Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
Cells, 2019 For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak +3 more
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Cysteine and Cysteine-Related Signaling Pathways in Arabidopsis thaliana [PDF]
Molecular Plant, 2014 Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor molecule involved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its derivative molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine is synthesized during
Romero González, Luis Carlos +5 more
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Molecules, 2021 Sentinel lymph node detection (SLND) is rapidly entering common practice in the management of patients with tumors. The introduction of mannose molecules to 99mTc-labeled dextrans, so far, showed that the sentinel node could trap these agents due to ...
Afroditi Papasavva +10 more
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Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements
Biosensors, 2021 The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances.
Kaveh Moulaee, Giovanni Neri
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Common Bean (Phaseolus vulgaris L.) Accumulates Most S-Methylcysteine as Its γ-Glutamyl Dipeptide
Plants, 2019 The common bean (Phaseolus vulgaris) constitutes an excellent source of vegetable dietary protein. However, there are sub-optimal levels of the essential amino acids, methionine and cysteine. On the other hand, P.
Elham Saboori-Robat +6 more
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The Non-Essential Amino Acid Cysteine Becomes Essential for Tumor Proliferation and Survival
Cancers, 2019 The non-essential amino acid cysteine is used within cells for multiple processes that rely on the chemistry of its thiol group. Under physiological conditions, many non-transformed tissues rely on glutathione, circulating cysteine, and the de novo ...
Joseph A. Combs, G. DeNicola
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