Results 51 to 60 of about 654,528 (315)
Cysteine Borylation in Unprotected Peptides [PDF]
, 2021 Synthetic bioconjugation at cysteine (Cys) residues in peptides and proteins has emerged as a powerful tool in chemistry. Soft nucleophilicity of the sulfur in Cys renders an exquisite chemoselectivity with which various functional groups can be placed ...
Alexander, Spokoyny +6 more
core +1 more source
NLRP3 Sensing of Diverse Inflammatory Stimuli Requires Distinct Structural Features
Frontiers in Immunology, 2020 The NLRP3 inflammasome is central to host defense and implicated in various inflammatory diseases and conditions. While the favored paradigm of NLRP3 inflammasome activation stipulates a unifying signal intermediate that de-represses NLRP3, this view has
Tabassum Rahman +5 more
doaj +1 more source
Structural and Kinetic Studies on the Formation of Platinum(II) and Palladium(II) Complexes with l-Cysteine-Derived Ligands [PDF]
, 2016 Complex-formation reactions of the l-cysteine-derived ligands αN-acetyl-S-methylene-(2‘-pyridine)-l-cysteine (py-CH2-accys) and αN-acetyl-S-ethylene-2-(2‘-pyridine)-l-cysteine (py-C2H4-accys) with [Pt(en)(H2O)2]2+ and [Pd(en)(H2O)2]2+ were investigated ...
Ralf Alsfasser (2711911) +3 more
core +1 more source
Beilstein Journal of Nanotechnology, 2019 This study was designed to evaluate the nano–bio interactions between endogenous biothiols (cysteine and glutathione) with biomedically relevant, metallic nanoparticles (silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs)), in order to assess the
Barbara Pem +8 more
doaj +1 more source
Frontiers in Plant Science, 2020 As a primary food crop, maize is widely grown around the world. However, the deficiency of essential amino acids, such as lysine, tryptophan, and methionine, results in poor nutritional quality of maize.
Shuoran Liu +5 more
doaj +1 more source
Antibiotics, 2022 Phylogenetically diverse fungal species are an increasing cause of severe disease and mortality. Identification of new targets and development of new fungicidal drugs are required to augment the effectiveness of current chemotherapy and counter ...
Gina Nicoletti, Kylie White
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibitors ...
Joana Magalhães +11 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
DATS-induced microtubule disarrangement and cell cycle arrest are cancelled by the pretreatment of the cell with -cysteine [PDF]
, 2011 Panel : HT-29 cells were cultured with vehicle (), 2 mM -cysteine (), 10 μM DATS () or both 10 μM DATS and 2 mM -cysteine () for 12 h. The microtubule distribution of the cells was assessed by the immunofluorescence method using anti-β-tubulin antibody ...
Isao Hasegawa (52806) +8 more
core +1 more source
Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance
Antioxidants, 2022 Deinococcus species possess remarkable tolerance to extreme environmental conditions that generate oxidative damage to macromolecules. Among enzymes fulfilling key functions in metabolism regulation and stress responses, thiol reductases (TRs) harbour ...
Arjan de Groot +3 more
doaj +1 more source