Results 71 to 80 of about 917,448 (310)

Multiple States of Nitrile Hydratase from Rhodococcus equi TG328-2: Structural and Mechanistic Insights from Electron Paramagnetic Resonance and Density Functional Theory Studies [PDF]

, 2017
Iron-type nitrile hydratases (NHases) contain an Fe(III) ion coordinated in a characteristic “claw setting” by an axial cysteine thiolate, two equatorial peptide nitrogens, the sulfur atoms of equatorial cysteine-sulfenic and cysteine-sulfinic acids, and
Stein, Natalia, Gumataotao, Natalie, Hajnas, Natalia, Wu, Rui, Wasantha Lankathilaka, Karunagala Pathiranage, Bornscheuer, Uwe, Liu, Dali, Fiedler, Adam T., Holz, Richard C., Bennett, Brian   +9 more
core   +1 more source

Import of cytochrome c into mitochondria [PDF]

, 1987
The import of cytochrome c into mitochondria can be resolved into a number of discrete steps. Here we report on the covalent attachment of heme to apocytochrome c by the enzyme cytochrome c heme lyase in mitochondria from Neurospora crassa. A new method
Basile G., Burnette W. N., Chance B., Dumont M. E., Ernst V., Estabrook R. W., Freitag H., Gasser S. M., Hackenbrock C. R., Hay R., Heller J., Hennig B., Hennig B., Hennig B., Kanarek L., Korb H., Laemmli U. K., Lederer F., Matner R. R., Matsuura S., Means G. E., Mihara K., Nicholson D. W., Nozaki M., Pelham H. R. B., Rietveld A., Rietveld A., Rietveld A., Rietveld A., Scarpulla R. C., Schmidt B., Sherman F., Stewart J. W., Taniuchi H., Taniuchi H., Towbin H., Veloso D., Visco C., Yuan P.-M., Zimmermann R., Zimmermann R., Zimmermann R., Zitomer R. S.   +42 more
core   +1 more source

On cysteine and cystine peptides. Part V. S-trityl- and S-diphenylmethyl-cysteine and -cysteine peptides

Journal of the Chemical Society C: Organic, 1970
A new method for the preparation of S-trityl-(i.e. triphenylmethyl) and S-diphenylmethyl-cysteines or -cysteine peptides involves treatment of cysteine or cysteine peptides with aralkylcarbinols in the presence of trifluoroacetic acid or hydrogen halides in acetic acid solution.
Photaki, I., Taylor-Papadimitriou, J., Sakarellos, C., Mazarakis, P., Zervas, L.   +4 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism [PDF]

, 2019
Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities.
Gao, Yan, Olson, Kenneth R.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Directed Evolution and Engineering of Gallium-Binding Phage Clones—A Preliminary Study

Biomimetics, 2019
The phage surface display technology is a useful tool to screen and to extend the spectrum of metal-binding protein structures provided by nature. The directed evolution approach allows identifying specific peptide ligands for metals that are less ...
Nora Schönberger, Christina Zeitler, Robert Braun, Franziska L. Lederer, Sabine Matys, Katrin Pollmann   +5 more
doaj   +1 more source

Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids

Frontiers in Microbiology, 2020
The sulfur-containing amino acids methionine and cysteine play an important role in food industry. These amino acids are used to confer a sulfur smell or meat-related aroma to food products.
Jhonatan A. Hernandez-Valdes, Maximillian M. Dalglish, Jos Hermans, Oscar P. Kuipers   +3 more
doaj   +1 more source

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

Symbiotic outcome modified by the diversification from 7 to over 700 nodule specific cysteine rich peptides [PDF]

, 2020
Legume-rhizobium symbiosis represents one of the most successfully co-evolved mutualisms. Within nodules, the bacterial cells undergo distinct metabolic and morphological changes and differentiate into nitrogen-fixing bacteroids.
Achom, Mingkee, Gifford, Miriam L., Lagunas, Beatriz, Roy, Proyash, Wilkinson, Helen   +4 more
core   +1 more source