Results 71 to 80 of about 747,792 (297)
Bulletin of the National Research Centre, 2019 Shortage of water is a major problem facing Egypt; thus, it becomes necessary to use non-traditional sources of water such as saline water in irrigation.
M. S. Sadak +4 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Directed Evolution and Engineering of Gallium-Binding Phage Clones—A Preliminary Study
Biomimetics, 2019 The phage surface display technology is a useful tool to screen and to extend the spectrum of metal-binding protein structures provided by nature. The directed evolution approach allows identifying specific peptide ligands for metals that are less ...
Nora Schönberger +5 more
doaj +1 more source
Development of Lactococcus lactis Biosensors for Detection of Sulfur-Containing Amino Acids
Frontiers in Microbiology, 2020 The sulfur-containing amino acids methionine and cysteine play an important role in food industry. These amino acids are used to confer a sulfur smell or meat-related aroma to food products.
Jhonatan A. Hernandez-Valdes +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
NanomaterialsChiral molecules are ubiquitous in nature and biological systems, where the unique optical and physical properties of chiral nanoparticles are closely linked to their shapes. Synthesizing chiral plasmonic nanomaterials with precise structures and tunable
Shengmiao Liu +2 more
doaj +1 more source
Frontiers in Plant Science, 2018 The application of amino acids in crops has been a common practice in recent years, although most of the time they are associated with products based on algae extracts or on fermented animal or vegetable wastes.
Walquíria F. Teixeira +5 more
doaj +1 more source
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.
Blood, 2019 We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from acute myeloid leukemia (AML) patients.
Courtney L Jones +10 more
semanticscholar +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source