Results 81 to 90 of about 747,792 (297)

Uso de aditivos químicos para a conservação pós-colheita de banana 'Maçã' minimamente processada Use of chemical additives for postharvest conservation of fresh cut 'Apple' Banana

Ciência e Agrotecnologia, 2009
Objetivou-se, neste trabalho, estudar o efeito de tratamentos com ácido ascórbico (AA), cloreto de cálcio (CC) e cloridrato de L-cisteína (LC) sobre a qualidade pós-colheita de banana 'Maçã' minimamente processada. Foram testadas as seguintes combinações:
Anderson Adriano Martins Melo, Eduardo Valério de Barros Vilas Boas, Cristina Filomena Justo   +2 more
doaj   +1 more source

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress

Nature Communications, 2018
Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated proteins and pathways is crucial to understand ROS-mediated events.
Jiska van der Reest, S. Lilla, Liang Zheng, S. Zanivan, E. Gottlieb   +4 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Chemical Proteomics Reveals New Targets of Cysteine Sulfinic Acid Reductase

Nature Chemical Biology, 2018
Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification (OxiPTM) that is known to be involved in redox-dependent regulation of protein function but has been historically difficult to analyze biochemically.
S. Akter, L. Fu, Youngeun Jung, Mauro Lo Conte, Mauro Lo Conte, J. R. Lawson, W. Lowther, Rui Sun, Keke Liu, Jing Yang, Kate S. Carroll   +10 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

ISOLATION OF CYSTEINE AND METHIONINE [PDF]

Basrah Journal of Veterinary Research, 2006
Random 'l‘n5 mutagenesis produced 2l cysteine/methionine and 13 methionine au.'otrophic mutants of‘ Sinorliiznbimn me/1'/or/' strain Rmd20l. Linkage of Tn5 to auxotroph indicated that each mutant had a single 'l‘n5 insertion.
BASIL A. ABBAS
doaj   +1 more source

Cysteine cathepsins: From structure, function and regulation to new frontiers

Biochimica et Biophysica Acta, 2011
It is more than 50 years since the lysosome was discovered. Since then its hydrolytic machinery, including proteases and other hydrolases, has been fairly well identified and characterized.
V. Turk, V. Stoka, O. Vasiljeva, M. Renko, T. Sun, B. Turk, D. Turk   +6 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cysteine reactivity across the subcellular universe.

Current Opinion in Chemical Biology, 2019
Cysteine residues are concentrated at key functional sites within proteins, performing diverse roles in metal binding, catalysis, and redox chemistry. Chemoproteomic platforms to interrogate the reactive cysteinome have developed significantly over the ...
Daniel W. Bak, Tyler J. Bechtel, J. A. Falco, E. Weerapana   +3 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source