Results 91 to 100 of about 827,600 (338)

Directed Evolution and Engineering of Gallium-Binding Phage Clones—A Preliminary Study

Biomimetics, 2019
The phage surface display technology is a useful tool to screen and to extend the spectrum of metal-binding protein structures provided by nature. The directed evolution approach allows identifying specific peptide ligands for metals that are less ...
Nora Schönberger, Christina Zeitler, Robert Braun, Franziska L. Lederer, Sabine Matys, Katrin Pollmann   +5 more
doaj   +1 more source

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Conversion of Methionine to Cysteine in Lactobacillus paracasei Depends on the Highly Mobile cysK-ctl-cysE Gene Cluster

Frontiers in Microbiology, 2018
Milk and dairy products are rich in nutrients and are therefore habitats for various microbiomes. However, the composition of nutrients can be quite diverse, in particular among the sulfur containing amino acids.
Daniel Wüthrich, Stefan Irmler, Hélène Berthoud, Barbara Guggenbühl, Elisabeth Eugster, Rémy Bruggmann   +5 more
doaj   +1 more source

Regulation of System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e-\u3c/sup\u3e by Pharmacological Manipulation of Cellular Thiols [PDF]

, 2015
The cystine/glutamate exchanger (system xc-) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system xc- can potentially cause excitotoxicity.
Albano, Rebecca, Baker, David, Hjelmhaug, Julie, Lobner, Doug, Raddatz, Nicholas J.   +4 more
core   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Effect of cysteine, insulin-like growth factor-1 and epidermis growth factor during in vitro oocyte maturation and in vitro culture of yak-cattle crossbred embryos

Journal of Applied Animal Research, 2019
Some antioxidants and growth factors play an important role in promoting oocyte maturation and embryo development in many mammalian species, but there is little information about the yak (Bos grunniens).
Rao-fen Yang, Xian-rong Xiong, Xiang-dong Zi   +2 more
doaj   +1 more source

β-n-oxalyl-l-α, β -diaminopropionic acid (β -odap) content in lathyrus sativus: The integration of nitrogen and sulfur metabolism through β -cyanoalanine synthase [PDF]

, 2017
Grass pea (Lathyrus sativus L.) is an important legume crop grown mainly in South Asia and Sub-Saharan Africa. This underutilized legume can withstand harsh environmental conditions including drought and flooding.
Chen, Peng, Jez, Joseph M, Krishnan, Hari B, Liu, Fengjuan, Xu, Quanle   +4 more
core   +3 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source