Results 231 to 240 of about 747,792 (297)

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming. [PDF]

Nat Metab
Wang Y, Shi H, Wittig J, Ren Y, Cordero J, Dewenter M, Mella J, Buchwalter A, Backs J, Wieland T, Heineke J, Fleming I, Bibli SI, Dobreva G.   +13 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Best practices for cysteine analysis. [PDF]

Ferroptosis Oxid Stress
Choudhury FK, DeNicola GM.
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Chemogenetic Manipulation of H₂S with Spatiotemporal Precision. [PDF]

Precis Chem
Ghaffari Zaki A, Issa H, Miri SM, Armouch J, Aydeger A, Yildirim S, Mete RZ, Aljundi O, Vatandaşlar E, Akgul Caglar T, Çimen Ş, Yiğit EN, Aydın MŞ, Alp Mİ, Almammadov T, Vilain S, Eroglu E.   +16 more
europepmc   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field. [PDF]

Front Mol Biosci
Chacón E, Grünwaldt G, Marmisolle I, Martínez J, Quijano C.   +4 more
europepmc   +1 more source