Results 51 to 60 of about 189,208 (289)

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Two special organelles found in Trypanosoma cruzi

Anais da Academia Brasileira de Ciências, 2000
We review here two unique organelles from Trypanosoma cruzi. One of them is the acidocalcisome, cytoplasmic vacuoles containing a very high Ca2+ concentration and a Ca2+ - H+ translocating ATPase activity, present in all trypanosomatids.
WANDERLEY DE SOUZA, ISABEL PORTO CARREIRO, KILDARE MIRANDA, NARCISA L. CUNHA E SILVA   +3 more
doaj   +1 more source

Propeptide-mediated inhibition of cognate gingipain proteinases. [PDF]

PLoS ONE, 2013
Porphyromonas gingivalis is a major pathogen associated with chronic periodontitis. The organism's cell-surface cysteine proteinases, the Arg-specific proteinases (RgpA, RgpB) and the Lys-specific proteinase (Kgp), which are known as gingipains have been
N Laila Huq, Christine A Seers, Elena C Y Toh, Stuart G Dashper, Nada Slakeski, Lianyi Zhang, Brent R Ward, Vincent Meuric, Dina Chen, Keith J Cross, Eric C Reynolds   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification and expression analysis of a novel phytocystatin in developing and germinating seeds of triticale (×Triticosecale Wittm.)

Acta Societatis Botanicorum Poloniae, 2015
In this paper the complete cDNA sequence of a newly identified triticale phytocystatin, TrcC-7, was analyzed. Because TrcC-7 transcripts were present in seeds, we hypothesized that it may regulate storage protein accumulation and degradation.
Joanna Simińska, Wiesław Bielawski
doaj   +1 more source

Cysteine Proteinase Inhibitors in Murine Cysticercosis [PDF]

Antimicrobial Agents and Chemotherapy, 2006
ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Salman, Baig, Raymond T, Damian, Jorge, Morales-Montor, Rupal, Thazhath, Amr, Ghaleb, Meredith, Welch, Jamil, Talhouk, A Clinton, White   +7 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Molecular karyotype and chromosomal localization of genes encoding ß-tubulin, cysteine proteinase, hsp 70 and actin in Trypanosoma rangeli

Memorias do Instituto Oswaldo Cruz, 2001
The molecular karyotype of nine Trypanosoma rangeli strains was analyzed by contour-clamped homogeneous electric field electrophoresis, followed by the chromosomal localization of ß-tubulin, cysteine proteinase, 70 kDa heat shock protein (hsp 70) and ...
CB Toaldo, M Steindel, MA Sousa, CC Tavares   +3 more
doaj   +1 more source

IMMUNODIAGNOSIS OF EGYPTIAN HUMAN FASCIOLOSIS GIGANTICA USING FAS1 AND FAS2 CYSTEINE PROTEINASE ANTIGENS [PDF]

Journal of the Egyptian Society of Parasitology, 2013
Fasciolosis caused by Fasciola gigantica is one of the major public health problems in the world including Egypt. Immunodiagnostic methods are more applicable for their better sensitivity and specificity than other methods.
ABEER BADR, NOHA MAHANA, IBRAHIM RABEE
doaj   +1 more source

Production of the cysteine proteinase inhibitor cystatin C by rat Sertoli cells [PDF]

, 1992
The Sertoli cells of the rat testis produce cystatin C, a cysteine proteinase inhibitor. Primary culture of Sertoli cells secreted both unglycosylated and glycosylated forms of rat cystatin C.
Esnard, Annick, Esnard, Frédéric, Francis Gauthierxaa, Annick Esnard, Guillou, Florian, Gauthier(xaa), Francis, Florian Guillou, Frédéric Esnard   +7 more
core   +1 more source