Results 71 to 80 of about 189,208 (289)
Electronic Journal of Biotechnology, 2015 Background: Cysteine proteinase inhibitor (cystatin, CPI) is one of the most important molecules involved in plant development and defense, especially in the regulation of stress responses.
Rui Li +6 more
doaj +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
Selective loss of cysteine residues and disulphide bonds in a potato proteinase inhibitor II family. [PDF]
PLoS ONE, 2011 Disulphide bonds between cysteine residues in proteins play a key role in protein folding, stability, and function. Loss of a disulphide bond is often associated with functional differentiation of the protein.
Xiu-Qing Li +2 more
doaj +1 more source
The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]
Biochemical Journal, 1986 A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane ...
P, Rauber +3 more
openaire +2 more sources
Streptococcal cysteine proteinase releases kinins: a novel virulence mechanism [PDF]
, 1996 Previous work has indicated a crucial role for the extracellular cysteine proteinase of Streptococcus pyogenes in the pathogenicity and virulence of this important human pathogen.
Björck, Lars +3 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Recombinant production and characterisation of two Fasciola hepatica cathepsin L proteases [PDF]
, 2005 The cysteine proteases of the liver fluke, Fasciola hepatica, are of great importance to the virulence of the organism. Previous work has established the involvement of these enzymes in catabolism, migration through host tissues and defence against host ...
Collins, Peter Raymond
core +2 more sources
Digestive enzymes of vine weevil (Otiorhynchus sulcatus) as potential targets for insect control strategies. [PDF]
, 2002 Over the previous quarter century the vine weevil (Otiorhynchus sulcatus) has become a pest of horticultural and agricultural plants. The vine weevil is a polyphagous coleopteran insect and is able to attack over one hundred different plant species.
Edwards, M.G., Edwards, Martin Gethin
core
Genetically Programmed Shape‐Morphing of Engineered Living Materials
Advanced Functional Materials, EarlyView.Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker +7 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2009 It has been shown previously that the laticifer fluid of Calotropis procera (Ait.) R.Br. is highly toxic to the egg hatching and larval development of Aedes aegypti L. In the present study, the larvicidal potential of other laticifer fluids obtained from
Márcio V Ramos +7 more
doaj +1 more source