Interdisciplinary Medicine, EarlyView.This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma +6 more
wiley +1 more source
A clinical SARS-CoV-2 Mpro inhibitor blocks replication of multiple enteroviruses and confers oral in vivo protection in animal models. [PDF]
PLoS PathogYe Z +13 more
europepmc +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
Trichinella spiralis serine proteinase enhances antibody-dependent cell-mediated (ADCC) killing of newborn larvae by driving M1 polarization via the NF-κB pathway. [PDF]
ParasiteWu JY +8 more
europepmc +1 more source
Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications
Journal of the Chinese Chemical Society, EarlyView.This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley +1 more source
Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. [PDF]
Protein SciTurner Z +9 more
europepmc +1 more source
Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex
Journal of the Chinese Chemical Society, EarlyView.In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley +1 more source
Computational insights into a protease inhibitor from Streptomyces globosus VITSMAB-2 molecular docking and dynamics simulations against SARS-CoV-2 main protease. [PDF]
Sci RepMishra S +3 more
europepmc +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Metabolic engineering of soybean for improving grain quality for animal consumption. [PDF]
Front Plant SciKafer JM +7 more
europepmc +1 more source