Results 1 to 10 of about 28,860 (95)
Cystatins — Inhibitors of Cysteine Proteinases [PDF]
Critical Reviews in Oral Biology & Medicine, 1992 The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C.
Libuse A. Bobek, Michael J. Levine
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The cystatins: Protein inhibitors of cysteine proteinases [PDF]
FEBS Letters, 1991 The last decade has witnessed enormous progress of protein inhibitors of cysteine proteinases concerning their structures, functions and evolutionary relationships. Although they differ in their molecular properties and biological distribution, they are structurally related proteins.
Wolfram Bode, Vito Turk
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Cysteine Proteinase Inhibitors in Murine Cysticercosis [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Jorge Morales-Montor +9 more
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The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein [PDF]
FEBS Letters, 1989 Peptide maps obtained by reversed‐phase HPLC of tryptic digests of isoelectric form 1 (pI=6.5) and 2 (pI=5.6) of chicken egg white cystatin revealed that the difference was located only in a single peptide (residues Ser‐74—Lys‐91). Ser‐80 of cystatin 2 was subsequently identified as being modified by phosphorylation.
Bernd Laber +6 more
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The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]
Biochemical Journal, 1986 A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane ...
Brian Walker +3 more
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A novel inhibitor protein for Bombyx cysteine proteinase is homologous to propeptide regions of cysteine proteinases [PDF]
FEBS Letters, 1999 A cDNA clone for an inhibitor of Bombyx cysteine proteinase was isolated and sequenced. Active inhibitor proteins were expressed in Escherichia coli using the cDNA. The open reading frame of the cDNA encodes a 105 residues protein with 19 residues of a signal sequence.
Susumu Y. Takahashi +3 more
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The primary structure of inhibitor of cysteine proteinases from potato [PDF]
FEBS Letters, 1993 The complete amino acid sequence of the cysteine proteinase inhibitor from potato tubers was determined. The inhibitor is a single‐chain protein having 180 amino acid residues. Its primary structure was elucidated by automatic degradation of the intact protein and sequence analysis of peptides generated by CNBr, trypsin and glycyl endopeptidase.
Roman Jerala +4 more
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Cystatin-like cysteine proteinase inhibitors of parasitic protozoa [PDF]
FEMS Microbiology Letters, 1992 A new method has been developed for detecting cystatins and other cysteine proteinase inhibitors. The method, which involves protein separation by SDS-PAGE followed by a cysteine proteinase overlay step, is more sensitive than previously reported techniques: as little as 1 ng of recombinant human cystatin C can be detected and cysteine proteinase ...
Graham H. Coombs +3 more
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The early history of intracellular cysteine proteinase inhibitors
Frontiers in Bioscience, 2010 Scientists at the beginning of their careers often rely on the information obtained from review articles. Furthermore, the review articles are commonly used by sponsors in making their funding decisions of scientific projects. Thus it is very important to give a balanced view of the past as well as the present of the field discussed in those papers. In
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Inhibition of cysteine proteinases by a protein inhibitor from potato
FEBS Letters, 1990 The inhibitory specificity of a protein from potato tubers that inhibits cysteine proteinases (potato cysteine proteinase inhibitor, PCPI) has been compared with that of chicken egg‐white cystatin. Most proteinases that are inhibited by cystatin were also inhibited by PCPI, but the potato inhibitor inhibited stem bromelain and fruit bromelain, which ...
Alan J. Barrett +3 more
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