Exploration of Microbially Derived Natural Compounds against Monkeypox Virus as Viral Core Cysteine Proteinase Inhibitors [PDF]
Viruses, 2023 Monkeypox virus (MPXV) is a member of the Orthopoxvirus genus and the Poxviridae family, which instigated a rising epidemic called monkeypox disease.
Amit Dubey +7 more
doaj +3 more sources
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors [PDF]
Antimicrobial Agents and Chemotherapy, 1996 We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine proteinase that is a critical hemoglobinase. In studies of cultured parasites, nanomolar concentrations of three vinyl sulfones inhibited parasite hemoglobin degradation ...
Philip J. Rosenthal +5 more
semanticscholar +4 more sources
Cystatin-like cysteine proteinase inhibitors from human liver [PDF]
Biochemical Journal, 1984 Cysteine proteinase inhibitor (CPI) forms from human liver were purified from the tissue homogenate by alkaline denaturation of cysteine proteinases with which they are complexed, acetone fractionation, affinity chromatography on S-carboxymethyl-papain-Sepharose and chromatofocusing.
G D J Green +3 more
semanticscholar +5 more sources
Cysteine proteinase inhibitors in murine cysticercosis. [PDF]
Antimicrob Agents Chemother, 2006 ABSTRACT We explored the prophylactic efficacies of two novel protease inhibitors in murine cysticercosis. Our results demonstrated a 95% and 80% reduction in parasite burden for mice injected with Z-LLL-FMK and Z-LLY-FMK, respectively. Further studies are merited on the role of cysteine proteinase inhibitors in treatment of cysticercosis.
Baig S +7 more
europepmc +4 more sources
Identification of Proteins Responsible for High Activity of Cysteine Proteinase Inhibitor in the Blood of Nile Tilapia Oreochromis niloticus [PDF]
Fishes, 2022 Cysteine proteinase inhibitors (CPIs) protect tissues and organs against cysteine proteinases in animal blood and have attracted much attention for use in food processing and medical sciences for humans and animals.
Seong Hee Mun, Joon Yeong Kwon
doaj +2 more sources
Computational investigation of potential natural compounds as inhibitors of monkeypox virus cysteine proteinase [PDF]
Frontiers in BioinformaticsIntroductionMonkeypox is a serious viral illness that is rarely seen but is spread from person to person and from animals to humans. Cysteine proteinase, an essential enzyme involved in the replication of the monkeypox virus (MPXV), is one of many ...
Riya Nalwa +10 more
doaj +2 more sources
Cystatin-like cysteine proteinase inhibitors of parasitic protozoa [PDF]
FEMS Microbiology Letters, 1992 A new method has been developed for detecting cystatins and other cysteine proteinase inhibitors. The method, which involves protein separation by SDS-PAGE followed by a cysteine proteinase overlay step, is more sensitive than previously reported techniques: as little as 1 ng of recombinant human cystatin C can be detected and cysteine proteinase ...
J W, Irvine, G H, Coombs, M J, North
openaire +3 more sources
Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors [PDF]
Biochemical Journal, 1989 F J Doherty +5 more
openalex +2 more sources
The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
doaj +1 more source