Results 101 to 110 of about 28,630 (299)

Functional characterization of a cystatin from the tick Rhipicephalus haemaphysaloides

Parasites & Vectors, 2015
Background Ticks and tick-borne diseases affect animal and human health worldwide and cause significant economic losses in the animal industry. Functional molecular research is important to understand the biological characteristics of ticks at the ...
Yujian Wang, Yongzhi Zhou, Haiyan Gong, Jie Cao, Houshuang Zhang, Xiangrui Li, Jinlin Zhou   +6 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Diagnostic value of serum cystatin C on newly diagnosed Parkinson's disease with mild cognitive impairment

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
 Objective To investigate the diagnostic value of expression level of serum cystatin C (Cys-C) on early diagnosis of newly diagnosed Parkinson's disease with mild cognitive impairment (PD-MCI).
Can-can MA, Bei-lei CHEN, Jun XU, Lan-lan CHEN, Yao XU, Cheng-lin YUAN, Xi-bin ZHANG, Hong-ying ZHANG, Jing-tao WU, Lin ZHOU   +9 more
doaj  

Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors

, 2017
Inflammation-induced bone destruction is a major treatment target in many inflammatory skeletal diseases. The aim of this study was to investigate if the cysteine proteinase inhibitors cystatin C, fungal cysteine proteinase inhibitor (E-64), and N ...
Anders Grubb, Lindholm, Catharina, Fredrik Strålberg, Stralberg, F., Kassem, Ali, Grubb, Anders,, Lindholm, Catharina,, Kasprzykowski, Franciszek,, Kasprzykowski, Franciszek, Kassem, A., Ali Kassem, Lerner, Ulf H,, Strålberg, Fredrik,, Strålberg, Fredrik, Ulf H Lerner, Catharina Lindholm, Kasprzykowski, F., Kassem, Ali,, Franciszek Kasprzykowski, Grubb, A., Grubb, Anders, Magnus Abrahamson, Lerner, Ulf H.,, Abrahamson, Magnus, Lerner, Ulf H, Abrahamson, M., Lund University., Abrahamson, Magnus,   +27 more
core   +1 more source

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts [PDF]

, 2004
Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by ...
Speth, Maria, Deibele, Karin, Neuhof, Heinz, Lubisch, Wilfried, Möller, Achim, Neuhof, Christiane, Fabiunke, Verena, Fritz, Hans, Tillmanns, Harald   +8 more
core   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Bacterial expression of human cysteine proteinase inhibitor stefin A

FEBS Letters, 1989
Gene expression system; DNA, recombinant; Stefin A; Cystatin ...
Fong, Dunne, Kartasova, Tonja, Sloane, Bonnie F., Chan, Marion Man-ying   +3 more
openaire   +2 more sources

Proteomic Deep Mining the Venom of the Red-Headed Krait, Bungarus flaviceps

Toxins, 2018
The use of -omics technologies allows for the characterization of snake venom composition at a fast rate and at high levels of detail. In the present study, we investigated the protein content of Red-headed Krait (Bungarus flaviceps) venom. This analysis
Alex Chapeaurouge, Andreza Silva, Paulo Carvalho, Ryan J. R. McCleary, Cassandra Marie Modahl, Jonas Perales, R. Manjunatha Kini, Stephen P. Mackessy   +7 more
doaj   +1 more source

β-Lactones as a New Class of Cysteine Proteinase Inhibitors:  Inhibition of Hepatitis A Virus 3C Proteinase by N-Cbz-serine β-Lactone

, 2016
N-Benzyloxycarbonyl-l-serine β-lactone (1) is shown to irreversibly inactivate the 3C cysteine proteinase of hepatitis A virus (HAV) with kinact = 0.70 min-1, KΙ = 1.84 × 10-4 M and kinact/KΙ = 3800 M-1 min-1 at an enzyme concentration of 0.1 μM.
Manjinder S. Lall (1936498), John C. Vederas (174316), Constantine Karvellas (3075444)   +2 more
core   +1 more source