Advanced Science, EarlyView.Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou +12 more
wiley +1 more source
In Silico Design, Extended Molecular Dynamic Simulations and Binding Energy Calculations for a New Series of Dually Acting Inhibitors against EGFR and HER2 [PDF]
arXiv, 2013 Starting from the lead structure we have identified in our previous works, we are extending our insight understanding of its potential inhibitory effect against both EGFR and HER2 receptors. Herein and using extended molecular dynamic simulations and different scoring techniques, we are providing plausible explanations for the observed inhibitory ...
arxiv
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica [PDF]
, 1997 Serge Ankri +4 more
openalex +1 more source
Advanced Science, EarlyView.Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo +9 more
wiley +1 more source
InhibiDistilbert: Knowledge Distillation for a ReLU and Addition-based Transformer [PDF]
arXivThis work explores optimizing transformer-based language models by integrating model compression techniques with inhibitor attention, a novel alternative attention mechanism. Inhibitor attention employs Manhattan distances and ReLU activations instead of the matrix multiplications and softmax activation of the conventional scaled dot-product attention.
arxiv
Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily [PDF]
, 1995 Veronika Stoka +6 more
openalex +1 more source
Substrate specificity and structural investigation into PepO and PepW : two peptidases from Lactobacillus rhamnosus : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]
, 2005 The proteolytic systems of lactic acid bacteria have important roles in the maturation and flavour development of cheese. Lactic acid bacteria pepetidases contribute to the taste of cheese through the production of low-molecular weight peptides and free ...
Yates, Karen Maree
core
Advanced Science, EarlyView.Carbon nanosol (CNS) exhibits rapid root penetration capacity, enhancing plant growth through boosting stomatal density and antioxidative enzyme activity. Single‐cell transcriptomic profiling uncovers cell type‐specific gene expression patterns and developmental trajectories during CNS‐mediated growth promotion.
Lingtong Cheng +10 more
wiley +1 more source
Correlation study on cystatin C and ischemic stroke
Chinese Journal of Contemporary Neurology and Neurosurgery, 2013 Objective To investigate the relationship between serum cystatin C (Cys C) and patients with acute ischemic stroke. Methods The clinical and laboratory data of 115 patients with acute ischemic stroke and 110 controls were recorded and analyzed.
Rong-bo CHEN, Wen-jie CHEN, Xuan ZHENG
doaj
Identification, Cloning, and Characterization of Cystatin M, a Novel Cysteine Proteinase Inhibitor, Down-regulated in Breast Cancer [PDF]
, 1997 Georgia Sotiropoulou +2 more
openalex +1 more source