Results 161 to 170 of about 753,077 (248)

Development of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening. [PDF]

J Med Chem
Cai Z, Li K, Sridhar S, Tan H, Demssie H, Fan G, Zhang W, Herrera BB, Wang J.   +8 more
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Proteinases and proteinase inhibitors in ejaculates of men with adnex affections [PDF]

, 1985
Krause, W., Rothauge, C. F., Weidner, W., Hofstetter, A., Brunner, H., Jochum, Marianne, Schießler, Hans, Friesen, A., Schill, W.-B., Fink, Edwin   +9 more
core   +1 more source

Targeted Reduction of Specific Antinutritional and Allergen-Associated Proteins to Advance Soybean Seed Quality. [PDF]

Int J Mol Sci
Krishnan HB, Kim W, Kim S, Nguyen TT.
europepmc   +1 more source

Helminth-derived stefin-1 selectively reduces leukemic cell viability and promotes apoptosis in U937 cells. [PDF]

PLoS One
Ploensil P, Suwanwong Y, Phannasil P, Tarasuk M, Thonsri U, Prapasitsin P, Martviset P, Chantree P.   +7 more
europepmc   +1 more source

Caco-2 Cell Co-Culture Alters the Molecular Size of Igl1 and Its Extracellular Fragments in <i>Entamoeba histolytica</i>. [PDF]

Pathogens
Kato K, Kudo M, Unno H, Hatakeyama T, Tachibana H.   +4 more
europepmc   +1 more source

Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia) [PDF]

, 1980
Fritz, Hans
core   +1 more source

Protein Proteinase Inhibitors in Male Sex Glands and their Secretions [PDF]

, 1973
Jaumann, Eugen, Schießler, Hans, Fritz, Hans, Werle, Eugen, Peeters, H., Förg-Brey, Bruni, Fink, Edwin   +6 more
core   +1 more source

Smolstatin1, a unique cystatin-like stefin of <i>Sphaerospora molnari</i>, is essential for parasite development. [PDF]

Curr Res Microb Sci
Bartošová-Sojková P, Dobai T, Kyslík J, Havlíčková P, Vancová M, Picard-Sánchez MA, Qadiri SSN, Martins LA, Urbanová V, Kosakyan A, Bílý T, Kale D, Kotál J, Chan JTH, Korytář T, Ludwig J, Smatanová IK, Holzer AS, Sojka D.   +18 more
europepmc   +1 more source