Results 181 to 190 of about 28,630 (299)

The Differential Redox Resilience of Alvelestat and Sivelestat: A Mechanistic Hypothesis for Inhibitor Performance Under Oxidative Stress. [PDF]

Molecules
D'Amato M, Linciano P, Chiarelli LR, Pietrocola G, Iadarola P, Collina S, Grignano MA, Gregorini M, Rampino T, Viglio S.   +9 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Stefin B and Cystatin C Deficiency Suppresses Tumor Growth and Alters Tumor Microenvironment in a Breast Cancer Model. [PDF]

Cells
Matjan Štefin P, Završnik J, Butinar M, Mikhaylov G, Turk B, Vasiljeva O.   +5 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

The pivotal role of β-lactone stereochemistry in the development of SARS-CoV-2 M^pro inhibitors. [PDF]

Protein Sci
Świderek K, Moliner V.
europepmc   +1 more source

Machine learning-driven docking of diverse DDAs as promising cysteine protease inhibitors targeting Mpox virus. [PDF]

In Silico Pharmacol
Alotaibi BS, Ahmad I, Almutairy B, Alkhammash A, Alsaiari AA, Khan K, Burki S.   +6 more
europepmc   +1 more source

Trichomonas vaginalis Drug Targets and Their Role in Drug Discovery and Development. [PDF]

Pharm Res
Alves MSD, Sena-Lopes Â, Moron LD, Fonseca BDR, Borsuk S.   +4 more
europepmc   +1 more source

Revisiting cysteine protease function in <i>Trypanosoma cruzi</i>: implications for parasite egress and differentiation. [PDF]

Microbiol Spectr
De Grandis S, Niggli A, Bogenstätter D, Lentini G.   +3 more
europepmc   +1 more source

Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review. [PDF]

Clin Oral Investig
Pedrosa ME, Martin V, Fernandes MH, Gomes PS.   +3 more
europepmc   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source